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View Structure Prediction Details

Protein: PRP6
Organism: Saccharomyces cerevisiae
Length: 899 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP6.

Description E-value Query
Range
Subject
Range
gi|71895939, gi|... - gi|71895939|ref|NP_001025642.1| MGC97740 protein [Xenopus (Silurana) tropicalis], gi|60550964|gb|AAH...
496.0 [0..2] [895..36]
CG6841-PA - This gene is referred to in FlyBase by the symbol Dmel\CG6841 (CG6841, FBgn0036828). It is a protein...
gi|220950366 - gi|220950366|gb|ACL87726.1| CG6841-PA [synthetic construct]
494.0 [0..3] [896..14]
PRPF6 - PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
491.0 [0..2] [895..4]
gi|55727663 - gi|55727663|emb|CAH90585.1| hypothetical protein [Pongo abelii]
PRP6_PONAB - Pre-mRNA-processing factor 6 OS=Pongo abelii GN=PRPF6 PE=2 SV=1
490.0 [0..2] [895..4]
gi|73992767 - gi|73992767|ref|XP_534481.2| PREDICTED: similar to U5 snRNP-associated 102 kDa protein [Canis famili...
488.0 [0..2] [895..63]
gi|50927247, gi|... - gi|50927247|gb|AAH79686.1| MGC80263 protein [Xenopus laevis], gi|148222496|ref|NP_001087374.1| MGC80...
488.0 [0..2] [895..12]
gi|114683093 - gi|114683093|ref|XP_001152053.1| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]
488.0 [0..2] [895..4]
gi|54641661, gi|... - gi|54641661|gb|EAL30411.1| GA19898-PA [Drosophila pseudoobscura], gi|125977754|ref|XP_001352910.1| G...
487.0 [0..3] [892..14]
PRP6_RAT - Pre-mRNA-processing factor 6 OS=Rattus norvegicus GN=Prpf6 PE=1 SV=1
486.0 [0..2] [895..4]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPSFLDQE PPAGYVPGIG RGATGFSTKE KQVVSNDDKG RRIPKRYREN LNNHLQSQPK  60
   61 DDEDDEAANV FKTLELKLAQ KKKKRANEKD DDNSVDSSNV KRQFADLKES LAAVTESEWM 120
  121 DIP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.670 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.670 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.654 N/A N/A a.24.3 Cytochromes
View Download 0.654 N/A N/A a.24.3 Cytochromes
View Download 0.601 N/A N/A a.24.3 Cytochromes
View Download 0.578 N/A N/A a.7.1 Spectrin repeat
View Download 0.578 N/A N/A a.7.1 Spectrin repeat
View Download 0.558 N/A N/A a.24.3 Cytochromes
View Download 0.529 N/A N/A a.24.3 Cytochromes
View Download 0.478 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore

Predicted Domain #2
Region A:
Residues: [124-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DATDFTRRNK RNRIQEQLNR KTYAAPDSLI PGNVDLNKLT EEREKLLQSQ IDENLAQLTK  60
   61 NASNPIQVNK PNAATDALSY LKDLENDRVN SLSDATLEDL QKMRTILKSY RKADPTNPQG 120
  121 WIASARLEEK ARKFSVAKKI IENGCQECPR S

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 14.34
Match:
Description: No description for 1qqeA was found.

Predicted Domain #3
Region A:
Residues: [275-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDIWLENIRL HESDVHYCKT LVATAINFNP TSPLLWFKAI DLESTTVNKY RVVRKALQEI  60
   61 PRDEGLWKLA VSFEADKAQV IKMLEKATQF IPQSMDLLTA YTNLQSYHNA KMTLNSFRKI 120
  121 LPQEPEIWII STLLEERNNP DIPVDKLVSL LKEGLLELSK NG

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 14.34
Match:
Description: No description for 1qqeA was found.

Predicted Domain #4
Region A:
Residues: [437-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKATLSAWLK RAEALNDAPN SNLTCQAIVY AILEWLRESG EYESELNNVD QILEKMPHSK  60
   61 VQIAVLKKLI QWDPCDTVLW SRLKMATESY HKIEELLAFF QELLFQTKNS DDIRANMREK 120
  121 SPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [560-766]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLMMYVSEYW KAQKGDTRQT LVLIDQIIDF APHNLDLRFF KIKLLGRSLQ LDELRDFFQQ  60
   61 TFSSLEDFKI SGTERLYYKY VNFLRYQDLN EEAIKFLNER CLKSFPICHK FFLQLGQIYH 120
  121 SMGNIEMSRE TYLSGTRLVP NCPLLWVSLS KIDEIDLKNP VRARSILDRG LLKNPDDVLF 180
  181 YIAKIQMEIR LGNLDQAELL VTQALQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [767-899]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPSNALLWVE QIKLFKHGNK SSLKKTIFQD ALRRTQNDHR VLLEIGVSFY AEAQYETSLK  60
   61 WLERALKKCS RYGDTWVWLF RTYARLGKDT VDLYNMFDQC EPTYGPEWIA ASKNVKMQYC 120
  121 TPREILLRLM NDK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.30103
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle