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Protein Overview: DUT1

General Information:
Name(s) found: DUT1 / YBR252W [SGD]
Description(s) found:
Found 28 descriptions.
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  • dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 147 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: pyrimidine deoxyribonucleoside triphosphate catabolic process [IMPLink to PubMed article]
    Molecular Function: dUTP diphosphatase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTATSDKVLK IQLRSASATV PTKGSATAAG YDIYASQDIT IPAMGQGMVS TDISFTVPVG  60
   61 TYGRIAPRSG LAVKNGIQTG AGVVDRDYTG EVKVVLFNHS QRDFAIKKGD RVAQLILEKI 120
  121 VDDAQIVVVD SLEESARGAG GFGSTGN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CDC15 CDC33 COF1 COR1 CPR1 CPR3 CYS4 DUG2 DUT1 GUS1 KGD1 PFK1 SEC53 TEF4 TEM1 TIF1, TIF2 TMA29 YGR066C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DUT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 154.626727 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleoside-triphosphate diphosphatase activity
    		•  5.64898078077484 bayes_pls_golite062009
  • dUTP diphosphatase activity
    		•  5.62861923551608 bayes_pls_golite062009
  • hydrolase activity
    		•  1.8120510491809 bayes_pls_golite062009
  • catalytic activity
    		•  1.71668532866244 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.43042083356989 bayes_pls_golite062009
  • binding
    		•  1.21193927389015 bayes_pls_golite062009
  • peroxisome proliferator activated receptor binding
    		•  1.01014631701573 bayes_pls_golite062009
  • pyrimidine deoxyribonucleotide binding
    		•  0.378438138772693 bayes_pls_golite062009
  • pyrimidine nucleotide binding
    		•  0.26077271033521 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle