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Protein Overview: GRR1

General Information:
Name(s) found: GRR1 / YJR090C [SGD]
Description(s) found:
Found 32 descriptions.
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  • F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1151 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cellular bud neck contractile ring [IDALink to PubMed articleLink to PubMed article]
    nuclear ubiquitin ligase complex [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    SCF ubiquitin ligase complex [IMPLink to PubMed article]
    Biological Process: G1/S transition of mitotic cell cycle [TASLink to PubMed article]
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IPILink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    cell cycle arrest in response to pheromone [IMPLink to PubMed article]
    protein ubiquitination [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]
    protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQDNNNHND SNRLHPPDIH PNLGPQLWLN SSGDFDDNNN NNNNNNNNNS TRPQMPSRTR  60
   61 ETATSERNAS EVRDATLNNI FRFDSIQRET LLPTNNGQPL NQNFSLTFQP QQQTNALNGI 120
  121 DINTVNTNLM NGVNVQIDQL NRLLPNLPEE ERKQIHEFKL IVGKKIQEFL VVIEKRRKKI 180
  181 LNEIELDNLK LKELRIDNSP QAISYLHKLQ RMRLRALETE NMEIRNLRLK ILTIIEEYKK 240
  241 SLYAYCHSKL RGQQVENPTD NFIIWINSID TTESSDLKEG LQDLSRYSRQ FINNVLSNPS 300
  301 NQNICTSVTR RSPVFALNML PSEILHLILD KLNQKYDIVK FLTVSKLWAE IIVKILYYRP 360
  361 HINKKSQLDL FLRTMKLTSE ETVFNYRLMI KRLNFSFVGD YMHDTELNYF VGCKNLERLT 420
  421 LVFCKHITSV PISAVLRGCK FLQSVDITGI RDVSDDVFDT LATYCPRVQG FYVPQARNVT 480
  481 FDSLRNFIVH SPMLKRIKIT ANNNMNDELV ELLANKCPLL VEVDITLSPN VTDSSLLKLL 540
  541 TRLVQLREFR ITHNTNITDN LFQELSKVVD DMPSLRLIDL SGCENITDKT IESIVNLAPK 600
  601 LRNVFLGKCS RITDASLFQL SKLGKNLQTV HFGHCFNITD NGVRALFHSC TRIQYVDFAC 660
  661 CTNLTNRTLY ELADLPKLKR IGLVKCTQMT DEGLLNMVSL RGRNDTLERV HLSYCSNLTI 720
  721 YPIYELLMSC PRLSHLSLTA VPSFLRPDIT MYCRPAPSDF SENQRQIFCV FSGKGVHKLR 780
  781 HYLVNLTSPA FGPHVDVNDV LTKYIRSKNL IFNGETLEDA LRRIITDLNQ DSAAIIAATG 840
  841 LNQINGLNND FLFQNINFER IDEVFSWYLN TFDGIRMSSE EVNSLLLQVN KTFCEDPFSD 900
  901 VDDDQDYVVA PGVNREINSE MCHIVRKFHE LNDHIDDFEV NVASLVRVQF QFTGFLLHEM 960
  961 TQTYMQMIEL NRQICLVQKT VQESGNIDYQ KGLLIWRLLF IDKFIMVVQK YKLSTVVLRL1020
 1021 YLKDNITLLT RQRELLIAHQ RSAWNNNNDN DANRNANNIV NIVSDAGAND TSNNETNNGN1080
 1081 DDNETENPNF WRQFGNRMQI SPDQMRNLQM GLRNQNMVRN NNNNTIDESM PDTAIDSQMD1140
 1141 EASGTPDEDM L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GRR1 SKP1
    View Details (MIPS) Mewes HW, et al. (2004) CDC34 CDC53 GRR1 SKP1
    View Details Krogan NJ, et al. (2006) CAK1 CDC34 CDC53 CDC9 CRT10 GRR1 MEP3 MET30 MMS1 POR1 RTT101 SAF1
    View Details Ho Y, et al. (2002) CDC53 COF1 CPR1 FOL2 GRR1 HTB2 PDC5 PDC6 PFK1 POR1 SAH1 SKP1 UBI4
    View Details Qiu et al. (2008) CDC4 GRR1 HRT1 MET30 UFO1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SKP1 GRR1 2 Uetz P, et al. (2000)
    View Screen SGT1 GRR1 2 Unpublished Fields Lab Data
    View Screen SKP1 GRR1 2 Unpublished Fields Lab Data
    View Screen SGT1 GRR1 2 Unpublished Fields Lab Data
    View Screen SKP1 GRR1 2 Unpublished Fields Lab Data
    View Screen SGT1 GRR1 2 Unpublished Fields Lab Data
    View Screen SGT1 GRR1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] deduced N/A No confident structure predictions are available.
    2 View Details [97..269] PSI-BLAST 4.39794 No description for 1k15A_ was found.
    3 View Details [270..332] deduced N/A No confident structure predictions are available.
    4 View Details [333..424] PSI-BLAST 15.522879 Ribonuclease inhibitor
    5 View Details [425..477] PSI-BLAST 15.522879 Ribonuclease inhibitor
    6 View Details [478..529] PSI-BLAST 15.522879 Ribonuclease inhibitor
    7 View Details [530..648] PSI-BLAST 15.522879 Ribonuclease inhibitor
    8 View Details [649..754] PSI-BLAST 15.522879 Ribonuclease inhibitor
    9 View Details [755..1045] PSI-BLAST 10.0 Leucine rich effector protein YopM
    10 View Details [1046..1151] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle