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Protein Overview: SAF1

General Information:
Name(s) found: SAF1 / YBR280C [SGD]
Description(s) found:
Found 19 descriptions.
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  • F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 637 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: proteasomal ubiquitin-dependent protein catabolic process [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVESREKE PDAGLSPDIV QATLPFLSSD DIKNLSQTNK YYNTLLDFDH SKILWHELFH  60
   61 KAFGTLKTND EPFQGRNSAE FKTCTETILR EAFPTLSWQE VYQLRAYDAK FYSWGYLKHG 120
  121 RLGYTASSNN ELVATSLNGP SPRFKYGVNT PTEVPWFNSR TTSRTSNFTP SEDPLSAIKK 180
  181 DGDEIIAQVS SGGFSFQILT ESGNLYSSGS TFSGGLKGPG PSGSQHDYNP FREMIHNMER 240
  241 SYPRITSRSN GSTVNTTGTF SGRRMSGSHP STAYEPGNAT TAQHITIDSG GAPAASPGGS 300
  301 HSGVPRTTMP SMGPHENIYS QIEMLERSAN KAVPGNNHIR RMFARNSFPL YSGRDENLGS 360
  361 FNDIQFVAVS SGRSHFLAMD TDNNIYSWDS TESDQGVKIE FANLPSRATN PILKIASGWN 420
  421 FNCCYIYKVG LVAWKERDAI QKGESFAFAK YEIVPNTNDV NGDSRIVDFA CLQDNCVFFI 480
  481 NNNGDKLWKY HNGLNQIVDL NIVGKLCKIN ACFASLVLFT DTHCYTLKVT NGDVDKDSLT 540
  541 ELDINENVIS VASGDYHTVA LTERGHLYSW GIESQDCGCL GLGPSEKIVN ELHIGNWEGQ 600
  601 RNIRVVKPTK IELPEDYICV SVTAGGWQTG ALIIKKH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC53 SAF1
    View Details Krogan NJ, et al. (2006) CAK1 CDC34 CDC53 CDC9 CRT10 GRR1 MEP3 MET30 MMS1 POR1 RTT101 SAF1
    View Details Ho Y, et al. (2002) AAH1 CDC53 PDC5 PDC6 PRB1 SAF1 THI21 YBR139W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..267] FFAS03 1.05 Regulator of chromosome condensation RCC1
    2 View Details [268..637] PSI-BLAST 60.69897 Regulator of chromosome condensation RCC1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.01485857731423 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  4.93236158049022 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.21249056267986 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.40166727602209 bayes_pls_golite062009
  • ligase activity
    		•  1.84832719690603 bayes_pls_golite062009
  • binding
    		•  0.720895345637233 bayes_pls_golite062009
  • catalytic activity
    		•  0.277477143337075 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.074598603744 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  4.98706956258248 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.24569482624066 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.41677849112717 bayes_pls_golite062009
  • ligase activity
    		•  1.85186470582778 bayes_pls_golite062009
  • binding
    		•  0.714930161612764 bayes_pls_golite062009
  • catalytic activity
    		•  0.261970921089142 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle