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Protein Overview: CDC34

General Information:
Name(s) found: CDC34 / YDR054C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 295 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    SCF ubiquitin ligase complex [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: G2/M transition of mitotic cell cycle [IGILink to PubMed articleLink to PubMed article]
    protein polyubiquitination [IDALink to PubMed article]
    G1/S transition of mitotic cell cycle [TASLink to PubMed article]
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDALink to PubMed articleLink to PubMed article]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [IDALink to PubMed articleLink to PubMed article]
    protein autoubiquitination [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRKSTASS LLLRQYRELT DPKKAIPSFH IELEDDSNIF TWNIGVMVLN EDSIYHGGFF  60
   61 KAQMRFPEDF PFSPPQFRFT PAIYHPNVYR DGRLCISILH QSGDPMTDEP DAETWSPVQT 120
  121 VESVLISIVS LLEDPNINSP ANVDAAVDYR KNPEQYKQRV KMEVERSKQD IPKGFIMPTS 180
  181 ESAYISQSKL DEPESNKDMA DNFWYDSDLD DDENGSVILQ DDDYDDGNNH IPFEDDDVYN 240
  241 YNDNDDDDER IEFEDDDDDD DDSIDNDSVM DRKQPHKAED ESEDVEDVER VSKKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC34 CDC53 HRT1 RTG2 RTT101 SKP1
    View Details (MIPS) Mewes HW, et al. (2004) CDC34 CDC4 CDC53 GRR1 MET30 SGT1 SKP1
    View Details Krogan NJ, et al. (2006) CAK1 CDC34 CDC53 CDC9 CRT10 GRR1 MEP3 MET30 MMS1 POR1 RTT101 SAF1
    View Details Qiu et al. (2008) CDC34 CDC4 CDC53 HRT1 SKP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CDC34 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] PSI-BLAST 44.045757 No description for 2ob4A was found.
    2 View Details [171..295] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle