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Protein Overview: MMS1

General Information:
Name(s) found: MMS1 / YPR164W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1407 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: DNA repair [IGILink to PubMed article][IMPLink to PubMed article]
    negative regulation of transposition, DNA-mediated [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGLRTHGLD RYEHYIRRPS DFGKLELQDW LNHKSFRVSP NLLIDSSTTR EWNEPELFYQ  60
   61 NTEDETWVRP CVGPKLEPSM MMLRYHDSNI GQMPQFCYPI SSPINFKPVL KYILQERSEL 120
  121 SDGFPQKYNT LIGSLFDIDK NPETLDDSDI EALDDIEMSS DSGNVKEPKI ELQALEEIQQ 180
  181 KHFSLIVSNN GIFQTGSTSI TYIQSGISGS IAIKPNNVAI LILLTQPSGH LLSILPLDDG 240
  241 KETYLLQYWN LGQKGQWNII KHQNEKQFVL IHKELGICKF FEFHLPFTFQ LVNNLTLTDS 300
  301 VIMNGSFFPT NYTDLDPYFI IFITAIRYER IVYFVIEWNN NEIKKKEVYQ LTVFDGEKTN 360
  361 MTIPIGLNAC LVETPLKFSL VSANQIMSGE TEFHSFQLKA LKGIKSFFPA PLLLLKLQEL 420
  421 HPHTFKKFQY CTIISSSTGN ICFCVTERST IVNGNLKFYE LTRFKGLKSI SPLPSNPINL 480
  481 DSRSSSYVLV VISFSRTLEL TLSLEDLRCL DKKDVIKPLK NITFKHTIDS STEENSQILA 540
  541 FTSSKFYNTH TGSNINDTRN SQVWLTSPNA ITQPCIDYKL RKTHQLIHLK QFQIFRHLRI 600
  601 WKCKNLDIAL LQRLGINQSN TESSLIFATD AVSNNRIFLL DLTMTTTIDN DDPVQGLINI 660
  661 EDLLCDTENE TILLNFTKNN LIQVTRDTIY IDPIGGDKEL RKISPGWEFE NVTYNDGILI 720
  721 VWNAGLGCVS YIENIDAVDE SGALVSNLSS SKGMSKFFKQ LGTVTSVNFQ IKESTDDPTK 780
  781 YDIWILLPDC VIRTPFSDWI SDSLDFSDVY ILSVQQALIN GPYFCSLDYE SYFEVHTLQN 840
  841 NCFKKGSRCT SRVNFQGKDI KFRSFGVNQC LAFSAFEIFV INLTPIHDSR ELDFYKLKLP 900
  901 HLGNNNSILE VCPDIENNQL FILYSDGLRI LELSYLTSNN GNFLLKSTRS KNKKFLYLDK 960
  961 INRMLVLNQD LREWECIRLS DGKAVGLDSQ LLKDDSEEIL EIKELPIATE DNPLEKKTVL1020
 1021 LISFTSSLKL VLLTAAKNKI SNQIIDSYKL DNSRLLNHLV ITPRGEIFFL DYKVMGTDNE1080
 1081 MSFNKLKVTK HCIDQEERNN TTLRLTLETR FTFKSWSTVK TFTVVGDNII ATTNMGEKLY1140
 1141 LIKDFSSSSD ESRRVYPLEM YPDSKVQKII PLNECCFVVA AYCGNRNDLD SRLIFYSLPT1200
 1201 IKVGLNNETG SLPDEYGNGR VDDIFEVDFP EGFQFGTMAL YDVLHGERHV NRYSEGIRSE1260
 1261 NDEAEVALRQ RRNLLLFWRN HSSTPKPSLR RAATIVYEDH VSSRYFEDIS SILGSTAMRT1320
 1321 KRLSPYNAVA LDKPIQDISY DPAVQTLYVL MADQTIHKFG KDRLPCQDEY EPRWNSGYLV1380
 1381 SRRSIVKSDL ICEVGLWNLS DNCKNTV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAK1 CDC34 CDC53 CDC9 CRT10 GRR1 MEP3 MET30 MMS1 POR1 RTT101 SAF1
    View Details Ho Y, et al. (2002) ADR1 BBC1 CDC39 CDC53 CRM1 DUR1,2 ECM29 ECM33 FAA4 GAL3 GCN1 HRT1 HYP2 MDN1 MKT1 MMS1 MYO2 PFK1 PMA2 RPA190 RPN1 TPS1 UBI4 VPS13 YAR009C YGP1 YLR035C-A

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1407] deduced N/A No confident structure predictions are available.
    2 View Details [140..252] deduced N/A No confident structure predictions are available.
    3 View Details [253..480] deduced N/A No confident structure predictions are available.
    4 View Details [481..551] deduced N/A No confident structure predictions are available.
    5 View Details [552..705] deduced N/A No confident structure predictions are available.
    6 View Details [706..857] deduced N/A No confident structure predictions are available.
    7 View Details [858..1061] deduced N/A No confident structure predictions are available.
    8 View Details [1062..1210] deduced N/A No confident structure predictions are available.
    9 View Details [1211..1407] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle