YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: SCF ubiquitin ligase complex
Acc: GO:0019005
Aspect: Cellular Component
Desc: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms:
  • Cul1-RING ubiquitin ligase complex
  • Skp1/Cul1/F-box protein complex
  • CDL1 complex
  • CRL1 complex
  • SCF complex
  • cullin-RING ligase 1
  • SCF complex substrate recognition subunit
Proteins in PDR annotated with:
   This term: 100 [Search]
   Term or descendants: 104 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0019005 - SCF ubiquitin ligase complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle