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Protein Overview: TMA19

General Information:
Name(s) found: TMA19 / YKL056C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 167 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IMPLink to PubMed article]
    translation [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIYKDIFSN DELLSDAYDA KLVDDVIYEA DCAMVNVGGD NIDIGANPSA EGGDDDVEEG  60
   61 AEMVNNVVHS FRLQQTAFDK KSFLTYIKGY MKAVKAKLQE TNPEEVPKFE KGAQTYVKKV 120
  121 IGSFKDWEFF TGESMDPDAM VVMLNYREDG TTPFVAIWKH GIVEEKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARO4 CAM1 TEF4 TMA19
    View Details Ho Y, et al. (2002) AAT2 ABP1 ACH1 ACO1 AFR1 AHA1 AHP1 AIM41 ARC1 ARF1 ATP3 ATP4 BRX1 BUD14 BUD3 CAR2 CCT2 CCT3 CCT6 CDC12 CDC33 CIN8 CLU1 COF1 COR1 CPR1 CRZ1 CYR1 CYS4 DCP1 DCP2 DNM1 DOG1 DOG2 EDC3 EDE1 EGD1 EGD2 ENP1 ERG13 ERG6 FPR1 FRS2 GAS1 GCN1 GCN3 GND1 GND2 GPG1 GPH1 GRX1 GUS1 HEF3 HHF1, HHF2 HIR1 HRR25 HSP104 HTB1 HXT7 HYP2 IMD4 IPP1 KRE33 LHS1 LOC1 LOS1 LRO1 LSP1 LTV1 MDH1 MDS3 MET6 MGE1 MGT1 MNP1 MSK1 NAN1 NOP56 NSA1 NTF2 NUG1 OLA1 OYE2 PEX19 PFK1 PIL1 PIN4 POL5 PRM2 PTC4 PUF3 PYC1 RAD54 RGD1 RIO2 RIP1 RNR2 RPC19 RPM2 RRP12 RSN1 RVB1 SAH1 SAP185 SAP190 SAS10 SCP160 SEC2 SEC23 SEC27 SEC53 SEC7 SEN15 SES1 SFB3 SGM1 SIT4 SNU13 SOD1 SOF1 SSD1 TEF4 THS1 TIF1, TIF2 TIF4631 TMA19 TSA2 TSR1 UBA1 UBC6 UBR1 UTP10 UTP20 UTP22 UTP7 VMA22 VMA4 VMA5 WTM1 YBR225W YER138C YHR033W YNK1 YPT1
    View Details Qiu et al. (2008) RPL18A, RPL18B RPP2B TMA19

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TMA19 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] PSI-BLAST 598.39794 Translationally controlled tumor-associated protein tctp, p23fyp

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on sulfur group of donors
    		•  3.4377744251418 bayes_pls_golite062009
  • protein-methionine-R-oxide reductase activity
    		•  3.14392283789517 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor
    		•  2.6167603393936 bayes_pls_golite062009
  • binding
    		•  2.26574571365153 bayes_pls_golite062009
  • transition metal ion binding
    		•  1.89566171684057 bayes_pls_golite062009
  • cation binding
    		•  1.8695053562775 bayes_pls_golite062009
  • metal ion binding
    		•  1.8695053562775 bayes_pls_golite062009
  • ion binding
    		•  1.86234474080078 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.14994807703391 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.009242671721 bayes_pls_golite062009
  • DNA binding
    		•  0.841663070276259 bayes_pls_golite062009
  • catalytic activity
    		•  0.566791077255496 bayes_pls_golite062009
  • protein binding
    		•  0.327945052023132 bayes_pls_golite062009
  • transcription factor activity
    		•  0.202907039530709 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle