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Protein Overview: RAD54

General Information:
Name(s) found: RAD54 / YGL163C [SGD]
Description(s) found:
Found 28 descriptions.
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  • DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 898 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IMPLink to PubMed article]
    Biological Process: chromatin remodeling [IDALink to PubMed article]
    heteroduplex formation [IDALink to PubMed article]
    [NOT]double-strand break repair via single-strand annealing [IMPLink to PubMed article]
    telomere maintenance via recombination [IMPLink to PubMed article]
    double-strand break repair via synthesis-dependent strand annealing [TASLink to PubMed article]
    Molecular Function: DNA-dependent ATPase activity [IDALink to PubMed article]
    DNA topoisomerase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARRRLPDRP PNGIGAGERP RLVPRPINVQ DSVNRLTKPF RVPYKNTHIP PAAGRIATGS  60
   61 DNIVGGRSLR KRSATVCYSG LDINADEAEY NSQDISFSQL TKRRKDALSA QRLAKDPTRL 120
  121 SHIQYTLRRS FTVPIKGYVQ RHSLPLTLGM KKKITPEPRP LHDPTDEFAI VLYDPSVDGE 180
  181 MIVHDTSMDN KEEESKKMIK STQEKDNINK EKNSQEERPT QRIGRHPALM TNGVRNKPLR 240
  241 ELLGDSENSA ENKKKFASVP VVIDPKLAKI LRPHQVEGVR FLYRCVTGLV MKDYLEAEAF 300
  301 NTSSEDPLKS DEKALTESQK TEQNNRGAYG CIMADEMGLG KTLQCIALMW TLLRQGPQGK 360
  361 RLIDKCIIVC PSSLVNNWAN ELIKWLGPNT LTPLAVDGKK SSMGGGNTTV SQAIHAWAQA 420
  421 QGRNIVKPVL IISYETLRRN VDQLKNCNVG LMLADEGHRL KNGDSLTFTA LDSISCPRRV 480
  481 ILSGTPIQND LSEYFALLSF SNPGLLGSRA EFRKNFENPI LRGRDADATD KEITKGEAQL 540
  541 QKLSTIVSKF IIRRTNDILA KYLPCKYEHV IFVNLKPLQN ELYNKLIKSR EVKKVVKGVG 600
  601 GSQPLRAIGI LKKLCNHPNL LNFEDEFDDE DDLELPDDYN MPGSKARDVQ TKYSAKFSIL 660
  661 ERFLHKIKTE SDDKIVLISN YTQTLDLIEK MCRYKHYSAV RLDGTMSINK RQKLVDRFND 720
  721 PEGQEFIFLL SSKAGGCGIN LIGANRLILM DPDWNPAADQ QALARVWRDG QKKDCFIYRF 780
  781 ISTGTIEEKI FQRQSMKMSL SSCVVDAKED VERLFSSDNL RQLFQKNENT ICETHETYHC 840
  841 KRCNAQGKQL KRAPAMLYGD ATTWNHLNHD ALEKTNDHLL KNEHHYNDIS FAFQYISH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) RAD51 RAD52 RAD54 RAD55 RAD57
    View Details Ho Y, et al. (2002) MDH1 MGE1 RAD54 TMA19
    View Details Qiu et al. (2008) RAD51 RAD54 RAD55 RAD57

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RAD54 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..223] MSA 1.238994 View MSA. No confident structure predictions are available.
    2 View Details [224..275] ORFEUS 13.09 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    3 View Details [276..583] ORFEUS 13.09 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    4 View Details [584..640] PSI-BLAST 8.221849 Putative DEAD box RNA helicase
    5 View Details [641..898] PSI-BLAST 7.045757 Nucleotide excision repair enzyme UvrB

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription repressor activity
    		•  3.46705970365511 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.2394894333307 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • chromatin binding
    		•  2.9265077396229 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.7870619298179 bayes_pls_golite062009
  • DNA binding
    		•  1.72304410722296 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • methylated histone residue binding
    		•  1.03331560428208 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.49996033797134 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.356338632175355 bayes_pls_golite062009
  • satellite DNA binding
    		•  0.327386416436959 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.309377712814897 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.296839540568239 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.29636000593974 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
    3
    Term Confidence Notes
  • microtubule motor activity
    		•  3.4297361345158 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  3.0989886302218 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  3.01886747063507 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.99763530427224 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.99650240285889 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • motor activity
    		•  2.60481158518321 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • hydrolase activity
    		•  1.77231681433173 bayes_pls_golite062009
  • ATPase activity
    		•  1.76238574289941 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.57826779898847 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.50574672650697 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.28029120876672 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • tubulin binding
    		•  1.01673904002272 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • microtubule binding
    		•  0.902404986889887 bayes_pls_golite062009
  • actin binding
    		•  0.875514430441177 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.773586048423911 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.559419947521782 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.40354211833657 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.244736544804496 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.144154288308693 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • GTPase activity
    		•  0.105546189348878 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.0289841199143713 bayes_pls_golite062009
  • translation regulator activity
    		•  0.0269721463618237 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.0187537754688351 bayes_pls_golite062009
  • GTP binding
    		•  0.0171298013679982 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.0028386101905622 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle