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Protein Overview: RAD57

General Information:
Name(s) found: RAD57 / YDR004W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 460 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: meiotic DNA recombinase assembly [IMPLink to PubMed article]
    heteroduplex formation [IDALink to PubMed article]
    [NOT]double-strand break repair via single-strand annealing [IMPLink to PubMed article]
    telomere maintenance via recombination [IMPLink to PubMed article]
    DNA recombinase assembly [IPILink to PubMed article]
    Molecular Function: DNA-dependent ATPase activity [ISSLink to PubMed article]
    protein heterodimerization activity [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRALSIKFD NTYMDLYDEL PESKLLYDEE FSYLLDAVRQ NGVCVVDFLT LTPKELARLI  60
   61 QRSINEVFRF QQLLVHEYNE KYLEICEKNS ISPDNGPECF TTADVAMDEL LGGGIFTHGI 120
  121 TEIFGESSTG KSQLLMQLAL SVQLSEPAGG LGGKCVYITT EGDLPTQRLE SMLSSRPAYE 180
  181 KLGITQSNIF TVSCNDLINQ EHIINVQLPI LLERSKGSIK LVIIDSISHH LRVELQNKSF 240
  241 RESQENKNYL DRMAEKLQIL AHDYSLSVVV ANQVGDKPLA NSPVAHRTYV TDYDYQLGWL 300
  301 VGWKNSTILY RQMNSLLGAS SNNDEILSDD EDYMLIERVM STVNDRNYDF FSKKKPPIIE 360
  361 NKTVERNSSS PISRQSKKRK FDYRVPNLGL TWSNHVSTRI LLQKSFKAST IIQRGEAHLY 420
  421 KGGDSASFWQ VKRTMKVVYS TFAKPGQIAY QITKRGIETA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) RAD51 RAD52 RAD54 RAD55 RAD57
    View Details Qiu et al. (2008) RAD51 RAD54 RAD55 RAD57

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RAD57 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] PSI-BLAST 18.522879 DNA repair protein Rad51, N-terminal domain
    2 View Details [62..359] PSI-BLAST 102.67837 RecA protein, ATPase-domain; RecA protein, C-terminal domain
    3 View Details [360..460] PSI-BLAST 102.67837 RecA protein, ATPase-domain; RecA protein, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.16381244011837 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.11265775498161 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.11046854230259 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.10134737488849 bayes_pls_golite062009
  • telomeric DNA binding
    		•  1.7692956079774 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.71882026185027 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • hydrolase activity
    		•  1.65763522573119 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.56989255954747 bayes_pls_golite062009
  • ATPase activity
    		•  1.53315090215319 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.08697924060619 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.08464552192299 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.91282941965371 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  0.88025547382722 bayes_pls_golite062009
  • DNA binding
    		•  0.702147676354075 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.701765069055282 bayes_pls_golite062009
  • double-stranded telomeric DNA binding
    		•  0.60383579317561 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • recombinase activity
    		•  0.45851158693664 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.287777990975748 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle