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Protein Overview: PYC1

General Information:
Name(s) found: PYC1 / YGL062W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1178 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed articleLink to PubMed article]
    Biological Process: gluconeogenesis [IMPLink to PubMed article]
    NADPH regeneration [TAS]
    Molecular Function: pyruvate carboxylase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQRKFAGLR DNFNLLGEKN KILVANRGEI PIRIFRTAHE LSMQTVAIYS HEDRLSTHKQ  60
   61 KADEAYVIGE VGQYTPVGAY LAIDEIISIA QKHQVDFIHP GYGFLSENSE FADKVVKAGI 120
  121 TWIGPPAEVI DSVGDKVSAR NLAAKANVPT VPGTPGPIET VEEALDFVNE YGYPVIIKAA 180
  181 FGGGGRGMRV VREGDDVADA FQRATSEART AFGNGTCFVE RFLDKPKHIE VQLLADNHGN 240
  241 VVHLFERDCS VQRRHQKVVE VAPAKTLPRE VRDAILTDAV KLAKECGYRN AGTAEFLVDN 300
  301 QNRHYFIEIN PRIQVEHTIT EEITGIDIVA AQIQIAAGAS LPQLGLFQDK ITTRGFAIQC 360
  361 RITTEDPAKN FQPDTGRIEV YRSAGGNGVR LDGGNAYAGT IISPHYDSML VKCSCSGSTY 420
  421 EIVRRKMIRA LIEFRIRGVK TNIPFLLTLL TNPVFIEGTY WTTFIDDTPQ LFQMVSSQNR 480
  481 AQKLLHYLAD VAVNGSSIKG QIGLPKLKSN PSVPHLHDAQ GNVINVTKSA PPSGWRQVLL 540
  541 EKGPAEFARQ VRQFNGTLLM DTTWRDAHQS LLATRVRTHD LATIAPTTAH ALAGRFALEC 600
  601 WGGATFDVAM RFLHEDPWER LRKLRSLVPN IPFQMLLRGA NGVAYSSLPD NAIDHFVKQA 660
  661 KDNGVDIFRV FDALNDLEQL KVGVDAVKKA GGVVEATVCF SGDMLQPGKK YNLDYYLEIA 720
  721 EKIVQMGTHI LGIKDMAGTM KPAAAKLLIG SLRAKYPDLP IHVHTHDSAG TAVASMTACA 780
  781 LAGADVVDVA INSMSGLTSQ PSINALLASL EGNIDTGINV EHVRELDAYW AEMRLLYSCF 840
  841 EADLKGPDPE VYQHEIPGGQ LTNLLFQAQQ LGLGEQWAET KRAYREANYL LGDIVKVTPT 900
  901 SKVVGDLAQF MVSNKLTSDD VRRLANSLDF PDSVMDFFEG LIGQPYGGFP EPFRSDVLRN 960
  961 KRRKLTCRPG LELEPFDLEK IREDLQNRFG DVDECDVASY NMYPRVYEDF QKMRETYGDL1020
 1021 SVLPTRSFLS PLETDEEIEV VIEQGKTLII KLQAVGDLNK KTGEREVYFD LNGEMRKIRV1080
 1081 ADRSQKVETV TKSKADMHDP LHIGAPMAGV IVEVKVHKGS LIKKGQPVAV LSAMKMEMII1140
 1141 SSPSDGQVKE VFVSDGENVD SSDLLVLLED QVPVETKA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PYC1 PYC2
    View Details Krogan NJ, et al. (2006) PYC1 PYC2 SPS1 TPM1
    View Details Ho Y, et al. (2002) ACC1 ACH1 ADH2 ADH3 ADR1 ARP7 CDC12 CDC60 DEF1 DIG1 DIG2 DOG1 DOG2 ECM10 FAA1 FET4 GCD11 GDE1 GFA1 GND1 GUS1 HAS1 HEF3 HIR3 HXT6 IDH2 IMD4 ISA2 KGD1 KSS1 MDH1 MET18 MET6 MKT1 MSE1 MSK1 NAP1 NGL2 PHO84 PIM1 PMA1 PRO2 PTC6 PYC1 PYC2 RAD1 RET1 RGC1 RGD1 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN10 RPN3 RPO26 RPO31 RVS167 SEC27 SEC53 SEN1 SML1 STE12 STE7 TBS1 TEC1 TFP1 TIF1, TIF2 TMA19 TPS1 TSA2 UBI4 VMA22 YDR239C YFL042C YHR033W YHR112C
    View Details Qiu et al. (2008) PYC1 PYC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PYC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] PSI-BLAST 1115.218487 No description for 1lsrA_ was found.
    2 View Details [129..135]
    [151..223]    		 PSI-BLAST 1115.218487 No description for 1lsrA_ was found.
    3 View Details [136..150]
    [224..249]
    [262..356]    		 PSI-BLAST 1115.218487 No description for 1lsrA_ was found.
    4 View Details [250..261]
    [357..508]    		 PSI-BLAST 1115.218487 No description for 1lsrA_ was found.
    5 View Details [509..893] ORFEUS 9.06 Betaine-homocysteine S-methyltransferase
    6 View Details [894..1014] ORFEUS 9.41 Dihydrodipicolinate synthase
    7 View Details [1015..1085] deduced N/A Confident ab initio structure predictions are available.
    8 View Details [1086..1178] PSI-BLAST 81.927757 Biotin carboxyl carrier domain of transcarboxylase (TC 1.3S)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle