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Protein Overview: PIM1

General Information:
Name(s) found: PIM1 / YBL022C [SGD]
Description(s) found:
Found 29 descriptions.
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  • ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1133 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: response to heat [IEPLink to PubMed article]
    proteolysis [IGILink to PubMed article]
    Molecular Function: ATP-dependent peptidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTRTTKTL STVARTTRAI QYYRSIAKTA AVSQRRFAST LTVRDVENIK PSHIIKSPTW  60
   61 QEFQHQLKDP RYMEHFAQLD AQFARHFMAT NSGKSILAKD DSTSQKKDED VKIVPDEKDT 120
  121 DNDVEPTRDD EIVNKDQEGE ASKNSRSSAS GGGQSSSSRS DSGDGSSKQK PPKDVPEVYP 180
  181 QMLALPIARR PLFPGFYKAV VISDERVMKA IKEMLDRQQP YIGAFMLKNS EEDTDVITDK 240
  241 NDVYDVGVLA QITSAFPSKD EKTGTETMTA LLYPHRRIKI DELFPPNEEK EKSKEQAKDT 300
  301 DTETTVVEDA NNPEDQESTS PATPKLEDIV VERIPDSELQ HHKRVEATEE ESEELDDIQE 360
  361 GEDINPTEFL KNYNVSLVNV LNLEDEPFDR KSPVINALTS EILKVFKEIS QLNTMFREQI 420
  421 ATFSASIQSA TTNIFEEPAR LADFAAAVSA GEEDELQDIL SSLNIEHRLE KSLLVLKKEL 480
  481 MNAELQNKIS KDVETKIQKR QREYYLMEQL KGIKRELGID DGRDKLIDTY KERIKSLKLP 540
  541 DSVQKIFDDE ITKLSTLETS MSEFGVIRNY LDWLTSIPWG KHSKEQYSIP RAKKILDEDH 600
  601 YGMVDVKDRI LEFIAVGKLL GKVDGKIICF VGPPGVGKTS IGKSIARALN RKFFRFSVGG 660
  661 MTDVAEIKGH RRTYIGALPG RVVQALKKCQ TQNPLILIDE IDKIGHGGIH GDPSAALLEV 720
  721 LDPEQNNSFL DNYLDIPIDL SKVLFVCTAN SLETIPRPLL DRMEVIELTG YVAEDKVKIA 780
  781 EQYLVPSAKK SAGLENSHVD MTEDAITALM KYYCRESGVR NLKKHIEKIY RKAALQVVKK 840
  841 LSIEDSPTSS ADSKPKESVS SEEKAENNAK SSSEKTKDNN SEKTSDDIEA LKTSEKINVS 900
  901 ISQKNLKDYV GPPVYTTDRL YETTPPGVVM GLAWTNMGGC SLYVESVLEQ PLHNCKHPTF 960
  961 ERTGQLGDVM KESSRLAYSF AKMYLAQKFP ENRFFEKASI HLHCPEGATP KDGPSAGVTM1020
 1021 ATSFLSLALN KSIDPTVAMT GELTLTGKVL RIGGLREKAV AAKRSGAKTI IFPKDNLNDW1080
 1081 EELPDNVKEG LEPLAADWYN DIFQKLFKDV NTKEGNSVWK AEFEILDAKK EKD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) MIS1 PIM1
    View Details Gavin AC, et al. (2002) IDH2 PIM1 SAM1
    View Details Ho Y, et al. (2002) ARP7 AVO1 BEM3 CCT2 COR1 CYS4 DIG1 DIG2 DOG1 ENP1 FET4 FPR3 GFA1 GUS1 HAS1 HXT6 KSS1 MAM33 MDN1 MKT1 MSE1 NAP1 NPA3 PEX6 PHO84 PIM1 PMA1 PRP8 PYC1 QCR2 RGC1 RPA135 RPN10 RPN6 RVB1 SAP185 SAP190 SEN1 SIT4 SNP1 SRP1 STE11 STE12 STE7 TEC1 TSC11 UBI4 USA1 VAC14 YDR239C YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PIM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] deduced N/A No confident structure predictions are available.
    2 View Details [156..387] Pfam 71.744727 ATP-dependent protease La (LON) domain No confident structure predictions are available.
    3 View Details [388..449] ORFEUS 7.54 delta subunit; delta subunit of DNA polymerase III, N-domain
    4 View Details [450..581] ORFEUS 7.54 delta subunit; delta subunit of DNA polymerase III, N-domain
    5 View Details [582..768] PSI-BLAST 62.221849 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    6 View Details [769..890] PSI-BLAST 62.221849 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    7 View Details [891..988] MSA 2.234996 View MSA. Confident ab initio structure predictions are available.
    8 View Details [989..1133] MSA 27.136997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.20426875618254 bayes_pls_golite062009
  • protein binding
    		•  0.594610587848879 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.533622874557729 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.505301584684092 bayes_pls_golite062009
  • catalytic activity
    		•  0.174240748624544 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ribonuclease activity
    		•  2.03745175432755 bayes_pls_golite062009
  • nuclease activity
    		•  1.83032641679211 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.38482286547386 bayes_pls_golite062009
  • hydrolase activity
    		•  1.18773479836745 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  1.16726450662143 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.1604717842042 bayes_pls_golite062009
  • structural molecule activity
    		•  1.14918348313691 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.13566902804592 bayes_pls_golite062009
  • ATP-dependent peptidase activity
    		•  0.99253423929971 bayes_pls_golite062009
  • binding
    		•  0.923114523007774 bayes_pls_golite062009
  • catalytic activity
    		•  0.878454819018611 bayes_pls_golite062009
  • peptidase activity
    		•  0.46678532223973 bayes_pls_golite062009
  • protein binding
    		•  0.398523921130957 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.227419965943609 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.161393552073973 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.0709817198603016 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  6.9430052008157E-5 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle