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Protein Overview: ADH3

General Information:
Name(s) found: ADH3 / YMR083W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 375 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: fermentation [ISSLink to PubMed article]
    NADH oxidation [IDALink to PubMed article]
    Molecular Function: alcohol dehydrogenase (NAD) activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTSTLFTR RVQPSLFSRN ILRLQSTAAI PKTQKGVIFY ENKGKLHYKD IPVPEPKPNE  60
   61 ILINVKYSGV CHTDLHAWHG DWPLPVKLPL VGGHEGAGVV VKLGSNVKGW KVGDLAGIKW 120
  121 LNGSCMTCEF CESGHESNCP DADLSGYTHD GSFQQFATAD AIQAAKIQQG TDLAEVAPIL 180
  181 CAGVTVYKAL KEADLKAGDW VAISGAAGGL GSLAVQYATA MGYRVLGIDA GEEKEKLFKK 240
  241 LGGEVFIDFT KTKNMVSDIQ EATKGGPHGV INVSVSEAAI SLSTEYVRPC GTVVLVGLPA 300
  301 NAYVKSEVFS HVVKSINIKG SYVGNRADTR EALDFFSRGL IKSPIKIVGL SELPKVYDLM 360
  361 EKGKILGRYV VDTSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADH1 ADH2 ADH3 ECM10 EFT2, EFT1 FAS1 HXK1 PDC6 RPL40B, RPL40A TDH1 YEF3
    View Details Krogan NJ, et al. (2006) ADH3 YBR062C
    View Details Gavin AC, et al. (2006) ADH3 NAM7
    View Details Ho Y, et al. (2002) ADH3 ECM10 HIR3 PYC1 SML1
    View Details Qiu et al. (2008) ADH1 ADH3 PAN5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ADH3 Huh WK, et al. (2003)
    View Data ADH3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180]
    [342..375]    		 PSI-BLAST 311.29073 Ketose reductase (sorbitol dehydrogenase)
    2 View Details [181..341] PSI-BLAST 311.29073 Ketose reductase (sorbitol dehydrogenase)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle