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Protein Overview: PAN5

General Information:
Name(s) found: PAN5 / YHR063C [SGD]
Description(s) found:
Found 25 descriptions.
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  • 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 379 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: pantothenate biosynthetic process [ISSLink to PubMed article]
    Molecular Function: 2-dehydropantoate 2-reductase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN GNNISIRKLY  60
   61 LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA LAPYLPYINK NTNLILIQNG 120
  121 LGVLELLREE IFTDSKNRPH LFQGVISHGV YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ 180
  181 KKSVVEDDAA NNSLVKLLTE PKFAKEFGIE HSTYQEMLFG QLFKFLVNAC MNPVTAILDC 240
  241 VNGEMKASCG PVFTSIIDEC LQILRVAYRP LFQYHEKYSG NEEYPEMDVN AVLTTDNMVS 300
  301 EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA DNLNLDPNCC KVNKTIGELA 360
  361 TMRLALNRSR SINGDWRKD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ADH3 PAN5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PAN5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 120.9794 Ketopantoate reductase PanE
    2 View Details [221..379] PSI-BLAST 120.9794 Ketopantoate reductase PanE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • phosphogluconate dehydrogenase (decarboxylating) activity
    		•  1.10855899772836 bayes_pls_golite062009
  • methylenetetrahydrofolate dehydrogenase activity
    		•  0.974298363844148 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  0.696602339330799 bayes_pls_golite062009
  • coenzyme binding
    		•  0.26743483421738 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.161344508455481 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.120113583068184 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.100470710829263 bayes_pls_golite062009
  • DNA binding
    		•  0.0870043837215047 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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