YRC Public Data Repository - Protein Structure Prediction

Protein:	PAN5
Organism:	Saccharomyces cerevisiae
Length:	379 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAN5.

Description	E-value	Query Range	Subject Range
PAN5 - 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. c... PANE_YEAST - 2-dehydropantoate 2-reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN5 PE=1 ... gi\|151944007 - gi\|151944007\|gb\|EDN62300.1\| 2-dehydropantoate 2-reductase [Saccharomyces cerevisiae YJM789]	2.0E-75	[1..379]	[1..379]
GPDA_STRMU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus mutans serotype c (strain ATCC 700610 ... GPDA_STRMU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus mutans GN=gpsA PE=3 SV=1	2.0E-60	[6..378]	[3..339]
GPDA_STRP1 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M1 GN=gpsA PE=3 SV=1 GPDA_STRP3 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M3 GN=gpsA PE=3 SV=1 GPDA_STRP8 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M18 GN=gpsA PE=3 SV=... GPDA_STRP8 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M18 (strain MGAS8232... GPDA_STRP3 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-... GPDA_STRPZ - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M49 (strain NZ131) G... gi\|56807554 - gi\|56807554\|ref\|ZP_00365474.1\| COG0240: Glycerol-3-phosphate dehydrogenase [Streptococcus pyogenes M... GPDA_STRPG - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M5 (strain Manfredo)... GPDA_STRPB - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M12 (strain MGAS2096... GPDA_STRPC - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M12 (strain MGAS9429... GPDA_STRPF - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M4 (strain MGAS10750... GPDA_STRPY - (P58143) Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (NAD(P)H-dependent glycerol-3-ph... GPDA_STRPQ - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pyogenes serotype M3 (strain SSI-1) GN... gi\|15674414, gi\|... - gi\|15674414\|ref\|NP_268588.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Streptococcus pyo...	3.0E-58	[6..379]	[3..334]
gi\|221319444 - gi\|221319444\|ref\|ZP_03600738.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... gi\|221314522 - gi\|221314522\|ref\|ZP_03596327.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... GPDA_BACSU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus subtilis (strain 168) GN=gpsA PE=3 SV=2 gi\|221323720 - gi\|221323720\|ref\|ZP_03605014.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... GPDA_BACSU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus subtilis GN=gpsA PE=3 SV=2	7.0E-58	[6..357]	[1..311]
GPDA_STRP7 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae (strain 70585) GN=gpsA PE=3... GPDA_STRZT - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae (strain Taiwan19F-14) GN=gp... GPDA_STRPN - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA... gi\|237650571 - gi\|237650571\|ref\|ZP_04524823.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Streptococcus ... GPDA_STRPN - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae GN=gpsA PE=3 SV=1 gi\|147763903, gi... - gi\|149011948\|ref\|ZP_01833096.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Streptococcus ... gi\|237821711 - gi\|237821711\|ref\|ZP_04597556.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Streptococcus ... gi\|149002920, gi... - gi\|149002920\|ref\|ZP_01827831.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Streptococcus ... gi\|242236995, gi... - gi\|242244522\|ref\|ZP_04798959.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Streptococcus ... gi\|168484398, gi... - gi\|172042345\|gb\|EDT50391.1\| glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol...	4.0E-57	[5..377]	[2..338]
gi\|221319444 - gi\|221319444\|ref\|ZP_03600738.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... gi\|221314522 - gi\|221314522\|ref\|ZP_03596327.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... GPDA_BACSU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus subtilis (strain 168) GN=gpsA PE=3 SV=2 gi\|221323720 - gi\|221323720\|ref\|ZP_03605014.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... GPDA_BACSU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus subtilis GN=gpsA PE=3 SV=2	5.0E-57	[6..357]	[1..311]
GPDA_STRZJ - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae (strain JJA) GN=gpsA PE=3 S... GPDA_STRR6 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) ... gi\|183574086, gi... - gi\|183574086\|gb\|EDT94614.1\| glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol... gi\|183576003, gi... - gi\|183576003\|gb\|EDT96531.1\| glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol... GPDA_STRPJ - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae (strain ATCC 700669 / Spain... GPDA_STRP2 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Streptococcus pneumoniae serotype 2 (strain D39 / NC... gi\|168489152, gi... - gi\|183572218\|gb\|EDT92746.1\| glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol... gi\|25283809 - pir\|\|C98109 glycerol-3-phosphate dehydrogenase [NAD(P)] (EC 1.1.1.94) [imported] - Streptococcus pne... gi\|148992065, gi... - gi\|148992065\|ref\|ZP_01821839.1\| (NAD(P)+) glycerol-3-phosphate dehydrogenase [Streptococcus pneumoni...	8.0E-57	[5..377]	[2..338]
GPDA_LACLA - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Lactococcus lactis subsp. lactis GN=gpsA PE=3 SV=1 GPDA_LACLA - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=...	2.0E-55	[7..379]	[4..336]
GPDA_BACHD - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus halodurans GN=gpsA PE=3 SV=1 GPDA_BACHD - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197...	3.0E-55	[6..357]	[1..310]
GPDA_LISIN - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=g... GPDA_LISIN - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Listeria innocua GN=gpsA PE=3 SV=1	5.0E-54	[1..366]	[1..323]

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Predicted Domain #1

Region A:
Residues: [1-220]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN GNNISIRKLY  60
   61 LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA LAPYLPYINK NTNLILIQNG 120
  121 LGVLELLREE IFTDSKNRPH LFQGVISHGV YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ 180
  181 KKSVVEDDAA NNSLVKLLTE PKFAKEFGIE HSTYQEMLFG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	120.9794
Match:	1ks9A_
Description:	Ketopantoate reductase PanE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.79741889688267	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	1.10855899772836	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.974298363844148	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.696602339330799	bayes_pls_golite062009
coenzyme binding	0.26743483421738	bayes_pls_golite062009
NAD or NADH binding	0.161344508455481	bayes_pls_golite062009
oxidoreductase activity	0.120113583068184	bayes_pls_golite062009
nucleic acid binding	0.100470710829263	bayes_pls_golite062009
DNA binding	0.0870043837215047	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [221-379]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLFKFLVNAC MNPVTAILDC VNGEMKASCG PVFTSIIDEC LQILRVAYRP LFQYHEKYSG  60
   61 NEEYPEMDVN AVLTTDNMVS EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA 120
  121 DNLNLDPNCC KVNKTIGELA TMRLALNRSR SINGDWRKD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	120.9794
Match:	1ks9A_
Description:	Ketopantoate reductase PanE
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: