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Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+. Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+. Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: methylenetetrahydrofolate dehydrogenase activity
Acc: GO:0004486
Aspect: Molecular Function
Desc: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
Synonyms:
  • N5,N10-methylenetetrahydrofolate dehydrogenase activity
  • 5,10-methylene-THF dehydrogenase activity
Proteins in PDR annotated with:
   This term: 19 [Search]
   Term or descendants: 35 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004486 - methylenetetrahydrofolate dehydrogenase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle