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Protein Overview: TPM1

General Information:
Name(s) found: TPM1 / YNL079C [SGD]
Description(s) found:
Found 39 descriptions.
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  • Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 199 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck contractile ring [IDALink to PubMed article]
    Biological Process: mitochondrion inheritance [TASLink to PubMed article]
    vacuole inheritance [TASLink to PubMed article]
    filamentous growth [IMPLink to PubMed article]
    budding cell isotropic bud growth [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    vesicle-mediated transport [TASLink to PubMed article]
    intracellular mRNA localization [TASLink to PubMed article]
    actin polymerization or depolymerization [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    actin filament organization [IPILink to PubMed article]
    exocytosis [TASLink to PubMed article]
    budding cell apical bud growth [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: actin lateral binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKIREKLSN LKLEAESWQE KYEELKEKNK DLEQENVEKE NQIKSLTVKN QQLEDEIEKL  60
   61 EAGLSDSKQT EQDNVEKENQ IKSLTVKNHQ LEEEIEKLEA ELAESKQLSE DSHHLQSNND 120
  121 NFSKKNQQLE EDLEESDTKL KETTEKLRES DLKADQLERR VAALEEQREE WERKNEELTV 180
  181 KYEDAKKELD EIAASLENL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Krogan NJ, et al. (2006) PYC1 PYC2 SPS1 TPM1
    View Details Qiu et al. (2008) ABP1 ABP140 ACT1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 ENT1 HOF1 IQG1 LAS17 MLC1 MLC2 MYO2 MYO4 PAN1 PFY1 RVS161 RVS167 SAC6 SCP1 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] PSI-BLAST 31.522879 Tropomyosin
    2 View Details [92..199] PSI-BLAST 31.522879 Tropomyosin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle