Protein Overview: MLC2

General Information:
Name(s) found:	MLC2 / YPR188C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring [SGD]
Organism:	Saccharomyces cerevisiae
Length:	163 amino acids
Gene Ontology:
Cellular Component:	cellular bud neck contractile ring [IDA]
Biological Process:	contractile ring contraction involved in cell cycle cytokinesis [IMP]
Molecular Function:	myosin II binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHSESLTFN QLTQDYINKL KDAFQMLDED EDGLISRGDL TKIYATLGKT LTDEEWSKMV  60
   61 PDNDTSTAEV GEEGVSFPIF LSIMGKNLSQ FPEREELEES LKAIGRGHDL NVPLNEVIDS 120
  121 LKEAGFENPE EEFAKLFKLF TTNQQATEER TFRGKLFLDS ITD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		MLC2 MYO1 YDR199W
View Details	Gavin AC, et al. (2002)		ACT1 ADH1 ARX1 GCN1 HSC82 KAP123 MLC1 MLC2 MYO1 MYO2 MYO4 NIP1 SHE2 SHE3 YEF3
View Details	Ho Y, et al. (2002)		CHD1 HSH49 MLC2 RSE1
View Details	Qiu et al. (2008)		BNR1 HOF1 IQG1 MLC1 MLC2 MYO1 MYO2 PFY1 TPM1 TPM2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MYO1	MLC2	2	Drees BL, et al. (2001)
View Screen	INP52	MLC2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	MLC2	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..88]	PSI-BLAST	126.70927	Calmodulin
2	View Details	[89..163]	PSI-BLAST	126.70927	Calmodulin

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2