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Protein Overview: BNR1

General Information:
Name(s) found: BNR1 / YIL159W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1375 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck contractile ring [IDALink to PubMed article]
    Biological Process: axial cellular bud site selection [IMPLink to PubMed article]
    response to osmotic stress [IGILink to PubMed article]
    actin filament organization [TASLink to PubMed article]
    Molecular Function: cytoskeletal protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSSPNKKTY RYPRRSLSLH ARDRVSEARK LEELNLNDGL VAAGLQLVGV ALEKQGTGSH  60
   61 IYMKQKNFSA NDVSSSPMVS EEVNGSEMDF NPKCMPQDAS LVERMFDELL KDGTFFWGAA 120
  121 YKNLQNISLR RKWLLICKIR SSNHWGKKKV TSSTTYSTHL ATNELAENAH FLDGLVRNLS 180
  181 TGGMKLSKAL YKLEKFLRKQ SFLQLFLKDE IYLTTLIEKT LPLISKELQF VYLRCFKILM 240
  241 NNPLARIRAL HSEPLIRWFT ELLTDQNSNL KCQLLSMELL LLLTYVEGST GCELIWDQLS 300
  301 ILFTDWLEWF DKILADDIAI HSSLYLNWNQ LKIDYSTTFL LLINSILQGF NNKTALEILN 360
  361 FLKKNNIHNT ITFLELAYKD DPNSVVIMEQ IKQFKSKESA IFDSMIKTTN DTNSLHPTKD 420
  421 IARIESEPLC LENCLLLKAK DSPVEAPINE IIQSLWKILD SQKPYSESIK LLKLINSLLF 480
  481 YLIDSFQVST NPSFDETLES AENVDYVFQD SVNKLLDSLQ SDEIARRAVT EIDDLNAKIS 540
  541 HLNEKLNLVE NHDKDHLIAK LDESESLISL KTKEIENLKL QLKATKKRLD QITTHQRLYD 600
  601 QPPSLASSNL SIAGSIIKNN SHGNIIFQNL AKKQQQQQKI SLPKRSTSLL KSKRVTSLSS 660
  661 YLTDANNENE SQNESEDKSK DSLFQRSTST INFNIPSMKN ITNMQNVSLN SILSELEFSN 720
  721 SLGTQPNYQS SPVLSSVSSS PKLFPRLSSD SLDNGIQLVP EVVKLPQLPP PPPPPPPPPL 780
  781 PQSLLTEAEA KPDGVSCIAA PAPPPLPDLF KTKTCGAVPP PPPPPPLPES LSMNKGPSNH 840
  841 DLVTPPAPPL PNGLLSSSSV SINPTTTDLK PPPTEKRLKQ IHWDKVEDIK DTLWEDTFQR 900
  901 QETIKELQTD GIFSQIEDIF KMKSPTKIAN KRNAESSIAL SSNNGKSSNE LKKISFLSRD 960
  961 LAQQFGINLH MFSQLSDMEF VMKVLNCDND IVQNVNILKF FCKEELVNIP KSMLNKYEPY1020
 1021 SQGKDGKAVS DLQRADRIFL ELCINLRFYW NARSKSLLTL STYERDYYDL IFKLQKIDDA1080
 1081 ISHLNRSPKF KSLMFIITEI GNHMNKRIVK GIKLKSLTKL AFVRSSIDQN VSFLHFIEKV1140
 1141 IRIKYPDIYG FVDDLKNIED LGKISLEHVE SECHEFHKKI EDLVTQFQVG KLSKEENLDP1200
 1201 RDQIIKKVKF KINRAKTKSE LLIGQCKLTL IDLNKLMKYY GEDPKDKESK NEFFQPFIEF1260
 1261 LAMFKKCAKE NIEKEEMERV YEQRKSLLDM RTSSNKKSNG SDENDGEKVN RDAVDLLISK1320
 1321 LREVKKDPEP LRRRKSTKLN EIAINVHEGD VKTRKDEDHV LLERTHAMLN DIQNI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BNR1 JJJ2 NOP56 NOP9
    View Details Ho Y, et al. (2002) ADR1 BMH1 BNR1 BOI2 CSR2 CYK3 GSY2 KCS1 NTH1 REG1 SOK1 STU1 SVL3 YFR017C YIL028W
    View Details Qiu et al. (2008) BEM1 BNI1 BNR1 BUD3 BUD6 ELM1 HOF1 IQG1 LAS17 MLC2 MYO1 MYO2 MYO4 PEA2 PFY1 PXL1 SPA2 SPH1 TPM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NSL1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MET30 BNR1 2 Unpublished Fields Lab Data
    View Screen PRP40 BNR1 2 Unpublished Fields Lab Data
    View Screen PRP40 BNR1 2 Unpublished Fields Lab Data
    View Screen SST2 BNR1 2 Unpublished Fields Lab Data
    View Screen SPO21 BNR1 2 Unpublished Fields Lab Data
    View Screen PFY1 BNR1 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BNR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] MSA 1.009996 View MSA. No confident structure predictions are available.
    2 View Details [163..291] ORFEUS 8.79 beta-Catenin
    3 View Details [292..393] ORFEUS 8.79 beta-Catenin
    4 View Details [394..522] ORFEUS 8.79 beta-Catenin
    5 View Details [523..603] ORFEUS 8.79 beta-Catenin
    6 View Details [604..665] PSI-BLAST 6.154902 Dynamin
    7 View Details [666..867] ORFEUS 11.94 Fibrinogen
    8 View Details [868..951] deduced N/A No confident structure predictions are available.
    9 View Details [952..999]
    [1069..1122]    		 ORFEUS 7.79 DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
    10 View Details [1000..1068]
    [1123..1200]    		 ORFEUS 7.79 DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
    11 View Details [1201..1323] ORFEUS 7.79 DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
    12 View Details [1324..1375] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • actin binding
    		•  3.34487439883854 bayes_pls_golite062009
  • binding
    		•  2.6374633159018 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • protein transporter activity
    		•  2.56209426863971 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.856755253686635 bayes_pls_golite062009
  • transporter activity
    		•  0.825258162383893 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.698613639309592 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.500493982824973 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.345785895390889 bayes_pls_golite062009
  • signal sequence binding
    		•  0.27824906981293 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.248376041999546 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.20813279031582 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.197447861665299 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.196910953077117 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0332743336452223 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.0268373969988844 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.00234756529236324 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • actin binding
    		•  4.76659069034376 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.48744511411671 bayes_pls_golite062009
  • actin filament binding
    		•  2.99963220150463 bayes_pls_golite062009
  • binding
    		•  2.86147407357315 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.64990514605397 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.25381967078645 bayes_pls_golite062009
  • profilin binding
    		•  0.91195854193678 bayes_pls_golite062009
  • small GTPase binding
    		•  0.8507658747425 bayes_pls_golite062009
  • GTPase binding
    		•  0.82889812790119 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.745321902095093 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.35466574267734 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.276130226777911 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.205756341419244 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.195095639672769 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.19455798195809 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  0.0524318525517602 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle