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Protein Overview: PEA2

General Information:
Name(s) found: PEA2 / YER149C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 420 amino acids

    Gene Ontology:
    Cellular Component: polarisome [TASLink to PubMed article]
    actin cap [IDALink to PubMed article]
    Biological Process: filamentous growth [IMPLink to PubMed article]
    bipolar cellular bud site selection [TASLink to PubMed article]
    regulation of initiation of mating projection growth [IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    actin filament organization [IPILink to PubMed article]
    regulation of termination of mating projection growth [IMPLink to PubMed article]
    Rho protein signal transduction [IPILink to PubMed article]
    Molecular Function: cytoskeletal regulatory protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKFDLELSR RANPLLFSAE RYEEYPLKYD ELKQYLLSQN PSHPHHNSRP YTSIDYFDYL  60
   61 LYRSKNDESE IDLDKKLVSE FALYYVQKEH LNSDDLNPTL NELLKLQPKS ADWYEMMLRI 120
  121 LESINTTGID QLTKENNNSF PNSKRARSST NMGGTDKFNK GAYHTDKADD DKNEILQELT 180
  181 SFLMSNSIQK GIDIKPIPLD DPVKFLKNGI NSILDTCVSL EKNTSSPPIS PNAAAIQEED 240
  241 SSKKLEELET AFSDLQLAHN FLTKQFENDR AEYVQDIEKL TRTNRELQDK LLNNHSNLSK 300
  301 TEKKLHELEQ ENKELEKANN KLNSSRHNFG MSSPASSPVT WDPSSPSSVG SPTSGSGSRS 360
  361 LSIMTSEFKK VLTSTQRKYE KELSDEREHR FKLERELALL KNAEANTSLA LNRDDPPDML 420
  421

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PEA2 SPA2
    View Details Krogan NJ, et al. (2006) BEM2 PEA2 SPA2
    View Details Qiu et al. (2008) BEM1 BNI1 BNR1 BOI1 BOI2 BUD6 CAP1 CDC42 CLA4 CRN1 END3 GIC1 GIC2 HOF1 HSK3 IQG1 LAS17 MLC1 MYO2 PAN1 PEA2 PFY1 PXL1 SLG1 SPA2 SPH1 TPM2 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PEA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] ORFEUS 7.29 Alpha chain
    2 View Details [138..420] ORFEUS 7.29 Alpha chain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle