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Protein Overview: CLA4

General Information:
Name(s) found: CLA4 / YNL298W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 842 amino acids

    Gene Ontology:
    Cellular Component: actin cap [IDALink to PubMed article]
    Biological Process: regulation of exit from mitosis [IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    Rho protein signal transduction [TASLink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    budding cell apical bud growth [IMPLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSAAANKI SDNDFQNIGP APRPPSSNSQ GRTCYNQTQP ITKLMSQLDL TSASHLGTST  60
   61 SKKKSGWVSY KDDGILSFIW QKRYLMLHDS YVALYKNDKQ NDDAILKIPL TSIISVSRTQ 120
  121 LKQYCFELVR CSDRNSVSSG SSSSLNVSSD SNSKKSIYIA TKTESDLHSW LDAIFAKCPL 180
  181 LSGVSSPTNF THKVHVGFDP ETGSFVGMPT NWEKLLKHSR ITGEDWNNNS AAVIQVLQFY 240
  241 QEYNGAGNPT NTLDKPQSGE TSSSQKSLPN SYNDNKLRNN SVNSKSSSGV SSSMVSQRKT 300
  301 SQPPNTKSPV SLGSGSLPPI NTKLPTSQSN IPRHLQNVPN QQYPKMRNGH SPTNGQFPRG 360
  361 PMHPNNSQRS LQQQQQQQQQ QKQQHQQYPY HHQGPSPSPS PSPSPLNPYR PHHNMINPYS 420
  421 KQPQSPLSSQ STQNQAIPRY AQNSSPTAAH FQPQRTAPKP PISAPRAPYP SNQNATSNTH 480
  481 VQPVAPKNDQ STPQTMRQAP KRPDADVAQP GGVAKPKKPA RPTMSTAEIM SKLKKVTVNA 540
  541 DPSQCFKVIE KAGQGASGSV YLAERTHIPT ESNMIELINN DIDEPHVGDK VAIKQMVLSK 600
  601 QPRKELIVNE ILVMKDSRHK NIVNFLEAYL RTDDDLWVVM EFMEGGSLTD IIENSPTNDN 660
  661 SHSPLTEPQI AYIVRETCQG LKFLHDKHII HRDIKSDNVL LDTRARVKIT DFGFCARLTD 720
  721 KRSKRATMVG TPYWMAPEVV KQREYDEKID VWSLGIMTIE MLEGEPPYLN EDPLKALYLI 780
  781 ATNGTPKLKH PESLSLEIKR FLSVCLCVDV RYRASTEELL HHGFFNMACD PKDLTSLLEW 840
  841 KE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ARK1 CLA4 PEA2 SLG1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MSB2 CLA4 2 Drees BL, et al. (2001)
    View Screen GIC1 CLA4 2 Drees BL, et al. (2001)
    View Screen SKG6 CLA4 2 Unpublished Fields Lab Data
    View Screen CDC42 CLA4 2 Drees BL, et al. (2001)
    View Screen ZDS2 CLA4 2 Drees BL, et al. (2001)
    View Screen SLA2 CLA4 2 Drees BL, et al. (2001)
    View Screen CLA4 CDC12 2 Drees BL, et al. (2001)
    View Screen CLA4 NUP100 2 Unpublished Fields Lab Data
    View Screen RGA1 CLA4 2 Drees BL, et al. (2001)
    View Screen BEM3 CLA4 2 Drees BL, et al. (2001)
    View Screen ABP1 CLA4 2 Drees BL, et al. (2001)
    View Screen GIC2 CLA4 2 Drees BL, et al. (2001)
    View Screen BOI2 CLA4 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CLA4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..177] ORFEUS 12.39 Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH
    2 View Details [178..258] PSI-BLAST 111.512579 pak1 autoregulatory domain
    3 View Details [259..461] ORFEUS 11.87 Fibrinogen
    4 View Details [462..642] PSI-BLAST 1004.0103 pak1
    5 View Details [643..842] PSI-BLAST 1004.0103 pak1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  4.60450391145449 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.36168834560682 bayes_pls_golite062009
  • binding
    		•  3.16245771986829 bayes_pls_golite062009
  • actin filament binding
    		•  2.88033925553037 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.60167278410043 bayes_pls_golite062009
  • protein binding
    		•  1.95763087285706 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.77594861208584 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.63593384010249 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.55414958698765 bayes_pls_golite062009
  • kinase activity
    		•  1.52393509273639 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51882027675546 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51882027675546 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.50594272418871 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.48917924547615 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.39413069155432 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36096357986245 bayes_pls_golite062009
  • transporter activity
    		•  1.29925758003665 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.20027540777757 bayes_pls_golite062009
  • receptor activity
    		•  1.18359632789069 bayes_pls_golite062009
  • receptor binding
    		•  1.17585427851367 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  1.15172245597736 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.13267118951633 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.12262165497943 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.10613306581585 bayes_pls_golite062009
  • transferase activity
    		•  1.09391396934652 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.0855213509529 bayes_pls_golite062009
  • DNA binding
    		•  1.05282014115313 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.975799143332123 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.902696448574164 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.830314446783898 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.77769334991472 bayes_pls_golite062009
  • Ran GTPase binding
    		•  0.709291241748316 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.650240628628722 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.62326150960884 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.578612934164552 bayes_pls_golite062009
  • small GTPase binding
    		•  0.56438433639766 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.552872712432362 bayes_pls_golite062009
  • GTPase binding
    		•  0.550421293582715 bayes_pls_golite062009
  • hydrolase activity
    		•  0.502607248848281 bayes_pls_golite062009
  • protein complex binding
    		•  0.424439033593144 bayes_pls_golite062009
  • profilin binding
    		•  0.356551348759974 bayes_pls_golite062009
  • structural molecule activity
    		•  0.332112521019418 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.328898130778985 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.262354991843615 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0707105517897648 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0620154731603239 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0594013389870999 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle