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Protein Overview: ARK1

General Information:
Name(s) found: ARK1 / YNL020C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 638 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: cytokinesis [IMPLink to PubMed article]
    actin filament organization [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of endocytosis [IMPLink to PubMed article]
    protein amino acid phosphorylation [IMPLink to PubMed article][ISSLink to PubMed article]
    actin cortical patch assembly [TASLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQPQIGTYN VGTQLTVGSH QVEIIKYLTS GGFAQVYSAL INPPDPHSNS SVACLKRVIV  60
   61 PDKPSLNTLR AEVDAMRLLK NNRYVVSYID SHAAKAMLHN GSYEVFVLME YCERGGLIDF 120
  121 MNTRLQNRLH EFEILQIMSQ VTQGVAAMHA LQPPLIHRDI KIENVLISAN NEYKLCDFGS 180
  181 VCGIIRPPRN SQELSYVQQD ILKNTTAQYR SPEMIDTFRG LPIDEKSDIW ALGIFLYKLC 240
  241 YYTTPFEKGG DLAILSGKFE FPLYPNYSEQ LKGLIRDILV QDPRHRPNVY QLLKRISIMQ 300
  301 NVPCPINDIQ VVQAPSSHLN LTELHQLSAT QNILSLNSPT TMENTMPNAT FQISMADNTT 360
  361 TAQMHPNRKP SQIAYDASFS NSAKGSQPLF DKSQNMYHAL DPPLVEPLAS SVSNNDNELK 420
  421 ANSATKLKQA IVSEAHTFRQ NNSIDFPLQN IIPQYEDSSS SSDESYSGDV DELKKTRSLG 480
  481 SYSTRGNIKK NQSVKESLTS SSLPGTSFTP TSTKVNLKHE NSPFKSTFVN TIDNSKDDLN 540
  541 KPSYEDLDVS KQNLKNSIQQ RMIDKLNSSE ESFNARKMSK VKLHEKGEID KPTMLKSSGP 600
  601 ISKDKKTKPT PPPKPSHLKP KPPPKPLLLA GRKLSLDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ARK1 CLA4 ENT1 PRK1 SLA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARK1 and SAC6 Huh WK, et al. (2003)
    View Data ARK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70]
    [89..110]    		 PSI-BLAST 221.741366 gamma-subunit of glycogen phosphorylase kinase (Phk)
    2 View Details [71..88]
    [111..335]    		 PSI-BLAST 221.741366 gamma-subunit of glycogen phosphorylase kinase (Phk)
    3 View Details [336..414] PSI-BLAST 12.0 Calmodulin
    4 View Details [415..521] PSI-BLAST 12.0 Calmodulin
    5 View Details [522..638] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

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    Created and Maintained by: Michael Riffle