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View Structure Prediction Details

Protein: CLA4
Organism: Saccharomyces cerevisiae
Length: 842 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLA4.

Description E-value Query
Range		 Subject
Range
gi|732944 - gi|732944|emb|CAA57879.1| protein kinase [Saccharomyces cerevisiae]
 0.0 [1..842] [1..842]
CLA4_ASHGO - Serine/threonine-protein kinase CLA4 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 ...
CLA4_ASHGO - Serine/threonine-protein kinase CLA4 OS=Ashbya gossypii GN=CLA4 PE=3 SV=1
 0.0 [1..842] [1..793]
gi|12744913 - gi|12744913|gb|AAK06844.1|AF332388_1 protein kinase STE20p [Pneumocystis carinii]
 0.0 [7..827] [2..686]
gi|50549363, gi|... - gi|50549363|ref|XP_502152.1| YALI0C22770p [Yarrowia lipolytica], gi|49648019|emb|CAG82472.1| YlCLA4 ...
gi|9653232, gi|4... - gi|9653232|gb|AAF81109.2|AF233061_1 protein kinase [Yarrowia lipolytica], gi|49648019|emb|CAG82472.1...
 0.0 [12..838] [5..914]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [264..842] [2..537]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
 0.0 [264..842] [2..537]
Pak-PC, Pak-PA, ... - The gene PAK-kinase is referred to in FlyBase by the symbol Dmel\Pak (CG10295, FBgn0014001). It is a...
 0.0 [127..838] [5..694]

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Predicted Domain #1
Region A:
Residues: [1-177] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSAAANKI SDNDFQNIGP APRPPSSNSQ GRTCYNQTQP ITKLMSQLDL TSASHLGTST  60
   61 SKKKSGWVSY KDDGILSFIW QKRYLMLHDS YVALYKNDKQ NDDAILKIPL TSIISVSRTQ 120
  121 LKQYCFELVR CSDRNSVSSG SSSSLNVSSD SNSKKSIYIA TKTESDLHSW LDAIFAK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 12.39
Match: 1faoA
Description: Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 4.60450391145449 bayes_pls_golite062009
cytoskeletal protein binding 3.36168834560682 bayes_pls_golite062009
binding 3.16245771986829 bayes_pls_golite062009
actin filament binding 2.88033925553037 bayes_pls_golite062009
insulin receptor binding 2.60167278410043 bayes_pls_golite062009
protein binding 1.95763087285706 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.77594861208584 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.63593384010249 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.55414958698765 bayes_pls_golite062009
kinase activity 1.52393509273639 bayes_pls_golite062009
molecular transducer activity 1.51882027675546 bayes_pls_golite062009
signal transducer activity 1.51882027675546 bayes_pls_golite062009
GTPase regulator activity 1.50594272418871 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.48917924547615 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.39413069155432 bayes_pls_golite062009
protein kinase activity 1.36096357986245 bayes_pls_golite062009
transporter activity 1.29925758003665 bayes_pls_golite062009
transcription regulator activity 1.20027540777757 bayes_pls_golite062009
receptor activity 1.18359632789069 bayes_pls_golite062009
receptor binding 1.17585427851367 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 1.15172245597736 bayes_pls_golite062009
enzyme regulator activity 1.13267118951633 bayes_pls_golite062009
transmembrane receptor activity 1.12262165497943 bayes_pls_golite062009
small GTPase regulator activity 1.10613306581585 bayes_pls_golite062009
transferase activity 1.09391396934652 bayes_pls_golite062009
nucleic acid binding 1.0855213509529 bayes_pls_golite062009
DNA binding 1.05282014115313 bayes_pls_golite062009
oxidoreductase activity 0.975799143332123 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.902696448574164 bayes_pls_golite062009
receptor signaling protein activity 0.830314446783898 bayes_pls_golite062009
SH2 domain binding 0.77769334991472 bayes_pls_golite062009
Ran GTPase binding 0.709291241748316 bayes_pls_golite062009
protein domain specific binding 0.650240628628722 bayes_pls_golite062009
protein serine/threonine kinase activity 0.62326150960884 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.578612934164552 bayes_pls_golite062009
small GTPase binding 0.56438433639766 bayes_pls_golite062009
substrate-specific transporter activity 0.552872712432362 bayes_pls_golite062009
GTPase binding 0.550421293582715 bayes_pls_golite062009
hydrolase activity 0.502607248848281 bayes_pls_golite062009
protein complex binding 0.424439033593144 bayes_pls_golite062009
profilin binding 0.356551348759974 bayes_pls_golite062009
structural molecule activity 0.332112521019418 bayes_pls_golite062009
structural constituent of cytoskeleton 0.328898130778985 bayes_pls_golite062009
structural constituent of muscle 0.262354991843615 bayes_pls_golite062009
pyrophosphatase activity 0.0707105517897648 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0620154731603239 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0594013389870999 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [178-258] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPLLSGVSSP TNFTHKVHVG FDPETGSFVG MPTNWEKLLK HSRITGEDWN NNSAAVIQVL  60
   61 QFYQEYNGAG NPTNTLDKPQ S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 111.512579
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [259-461] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GETSSSQKSL PNSYNDNKLR NNSVNSKSSS GVSSSMVSQR KTSQPPNTKS PVSLGSGSLP  60
   61 PINTKLPTSQ SNIPRHLQNV PNQQYPKMRN GHSPTNGQFP RGPMHPNNSQ RSLQQQQQQQ 120
  121 QQQKQQHQQY PYHHQGPSPS PSPSPSPLNP YRPHHNMINP YSKQPQSPLS SQSTQNQAIP 180
  181 RYAQNSSPTA AHFQPQRTAP KPP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.87
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [462-642] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISAPRAPYPS NQNATSNTHV QPVAPKNDQS TPQTMRQAPK RPDADVAQPG GVAKPKKPAR  60
   61 PTMSTAEIMS KLKKVTVNAD PSQCFKVIEK AGQGASGSVY LAERTHIPTE SNMIELINND 120
  121 IDEPHVGDKV AIKQMVLSKQ PRKELIVNEI LVMKDSRHKN IVNFLEAYLR TDDDLWVVME 180
  181 F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1004.0103
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [643-842] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGGSLTDII ENSPTNDNSH SPLTEPQIAY IVRETCQGLK FLHDKHIIHR DIKSDNVLLD  60
   61 TRARVKITDF GFCARLTDKR SKRATMVGTP YWMAPEVVKQ REYDEKIDVW SLGIMTIEML 120
  121 EGEPPYLNED PLKALYLIAT NGTPKLKHPE SLSLEIKRFL SVCLCVDVRY RASTEELLHH 180
  181 GFFNMACDPK DLTSLLEWKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1004.0103
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle