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Protein Overview: Pak-PC, Pak-PA, ...

General Information:
Name(s) found: FBpp0306611 [FlyBase]
FBpp0306606 [FlyBase]
Pak-PB / FBpp0081213 [FlyBase]
Pak-PA / FBpp0081212 [FlyBase]
Pak-PC / FBpp0081211 [FlyBase]
Description(s) found:
Found 60 descriptions.
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  • type=protein; loc=3R:join(2180743..2180902,2180988..2181142,2182155..2182320,2182472..2183062,2184005..2184744,2184814..2185032,2185104..2185187); ID=FBpp0306611; name=Pak-PJ; parent=FBgn0014001,FBtr0334544; dbxref=FlyBase:FBpp0306611,FlyBase_Annotation_IDs:CG10295-PJ,REFSEQ:NP_001262313,GB_protein:AGB95696; MD5=e0608195a920e28eb8e5d07440e3a97d; length=704; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=3R:join(2180743..2180902,2180988..2181142,2182155..2182320,2182472..2183062,2184005..2184744,2184814..2185032,2185104..2185187); ID=FBpp0306606; name=Pak-PE; parent=FBgn0014001,FBtr0334539; dbxref=FlyBase:FBpp0306606,FlyBase_Annotation_IDs:CG10295-PE,REFSEQ:NP_001262309,GB_protein:AGB95692; MD5=e0608195a920e28eb8e5d07440e3a97d; length=704; release=r5.56; species=Dmel; [FlyBase]
  • The gene PAK-kinase is referred to in FlyBase by the symbol Dmel\Pak (CG10295, FBgn0014001). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2176620..2185974. It has the cytological map location 83E4. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; dorsal closure; regulation of axonogenesis; axon guidance; cell adhesion; regulation of synapse structure and activity. 46 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: adult segment; multi-cell-component structure; antennal segment; adult brain; antennal glomerular array DM3 (anterior); nervous system; abdominal segmental nerve; postsynaptic membrane; imaginal precursor; peripheral nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene PAK-kinase is referred to in FlyBase by the symbol Dmel\Pak (CG10295, FBgn0014001). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2176620..2185974. It has the cytological map location 83E4. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; dorsal closure; regulation of axonogenesis; axon guidance; cell adhesion; regulation of synapse structure and activity. 46 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: adult segment; multi-cell-component structure; antennal segment; adult brain; antennal glomerular array DM3 (anterior); nervous system; abdominal segmental nerve; postsynaptic membrane; imaginal precursor; peripheral nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene PAK-kinase is referred to in FlyBase by the symbol Dmel\Pak (CG10295, FBgn0014001). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2176620..2185974. It has the cytological map location 83E4. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; dorsal closure; regulation of axonogenesis; axon guidance; cell adhesion; regulation of synapse structure and activity. 46 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: adult segment; multi-cell-component structure; antennal segment; adult brain; antennal glomerular array DM3 (anterior); nervous system; abdominal segmental nerve; postsynaptic membrane; imaginal precursor; peripheral nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 704 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IMP]
    focal adhesion [IDA]
    Biological Process: dorsal closure [IMP][TAS]
    Rac protein signal transduction [NAS]
    regulation of cell shape [IMP]
    regulation of axonogenesis [IGI]
    regulation of synapse structure and activity [IMP]
    axon guidance [IGI][IMP][IPI][TAS]
    cell adhesion [IDA]
    JNK cascade [NAS]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    protein serine/threonine kinase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEEDKPPA PPVRLTSNRG GNERSGGGVG VGGGGLGGGG MGDVPPDMRP LPKEPDDSDR  60
   61 KKKTLKSKIK GSKPSHTDSK PNISYPTNFE HTVHVGFDAV TGEFTGMPEA WARLLMNSNI 120
  121 SKQEQKKNPQ AVLDVLKWFD NTTKQRPSSK YMTNAITTHS GSSLSRVSSS SPSSTPTDSE 180
  181 LHGSNSGGNL IGVQLGSMTL GPNANNVAVA GQILGNHYQQ QQQHLLQQQQ PLLHQNHNQH 240
  241 HMGISQSHSY NFVGHTVSSS TSQHSSANED DMLGPQHPQQ QPPPPPVASR PERTKSIYTR 300
  301 PIEDLQPAII PMPVAPATTP ATPLQNHRTP GGISAPAASP MMHNNATTTL DKNKNNANLY 360
  361 TPEPTVAQVS AGGPSSQVAG NQIAVPQAAV APAATPNTRA ANAKKKKMSD EEILEKLRTI 420
  421 VSVGDPNRKY TKMEKIGQGA SGTVYTAIES STGMEVAIKQ MNLSQQPKKE LIINEILVMR 480
  481 ENKHPNVVNY LDSYLVSEEL WVVMEYLPGG SLTDVVTETC MDEGQIAAVC REVLQALEFL 540
  541 HANQVIHRDI KSDNILLGLD GSVKLTDFGF CAQISPEQSK RTTMVGTPYW MAPEVVTRKQ 600
  601 YGPKVDLWSL GIMAIEMVEG EPPYLNENPL KALYLIATNG KPEIKEKDKL SSAFQDFLDQ 660
  661 CLEVEVDRRA SALDLLKHPF LKLARPLASL TPLIMAAKEA TKGN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] PSI-BLAST 21.0 pak1 autoregulatory domain
    2 View Details [147..275] deduced N/A No confident structure predictions are available.
    3 View Details [276..402] FFAS03 1.09 No description for 2j63A was found.
    4 View Details [403..704] PSI-BLAST 88.154902 pak1


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle