YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress. The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK). The process of introducing a phosphate group into a JUN protein. The initiation of the activity of the inactive enzyme JUN kinase kinase kinase activity in response to phosphorylation by a member of the MAP kinase kinase kinase kinase (MAPKKKK) family or another upstream kinase. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: JNK cascade
Acc: GO:0007254
Aspect: Biological Process
Desc: A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
Synonyms:
  • MAPK8 cascade
  • JNK1 cascade
  • stress-activated protein kinase cascade
  • JNK3 cascade
  • MAPK9 cascade
  • MAPK10 cascade
  • SAPK cascade
  • JNK2 cascade
Proteins in PDR annotated with:
   This term: 106 [Search]
   Term or descendants: 277 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007254 - JNK cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle