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Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Modulates the rate of GTP hydrolysis by a small monomeric GTPase. Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: Rho guanyl-nucleotide exchange factor activity
Acc: GO:0005089
Aspect: Molecular Function
Desc: Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
Synonyms:
  • RhoGEF
  • Rho guanine nucleotide exchange factor
Proteins in PDR annotated with:
   This term: 344 [Search]
   Term or descendants: 346 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005089 - Rho guanyl-nucleotide exchange factor activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle