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Protein Overview: MSB2

General Information:
Name(s) found: MSB2 / YGR014W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1306 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IMPLink to PubMed article][ISSLink to PubMed article]
    site of polarized growth [IDALink to PubMed article]
    Biological Process: response to osmotic stress [IMPLink to PubMed article]
    signal transduction during filamentous growth [IEPLink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: osmosensor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQFPFACLLS TLVISGSLAR ASPFDFIFGN GTQQAQSQSE SQGQVSFTNE ASQDSSTTSL  60
   61 VTAYSQGVHS HQSATIVSAT ISSLPSTWYD ASSTSQTSVS YASQESDYAV NQNSWSASTN 120
  121 QLPSTSTTSY YAPTFSTSAD FAASSVNAAS DVSTASVPID TSANSIPFTT TSNIETTTSA 180
  181 PLTSDTPLIS TSTMSAADNV FSSANPISAS LTTTDSSESF DQTSTAGAIP VQSSADFSSS 240
  241 SEILVQSSAD FSSPSSPTTT DISLSAAPLQ TSESSSFTTA SAALPVSSTD VDGSSASPVV 300
  301 SMSAAGQIAS SSSTDNPTMS ETFSLTSTEV DGSDVSSTVS ALLSAPFLQT STSNSFSIVS 360
  361 PSVSFVPSQS SSDVASSSTA NVVSSSFSDI PPQTSTSGSV VSVAQSASAL AFQSSTEVYG 420
  421 ASASSTMSSL LSTTSLQSTT LDSSSLASSS ASSSDLTDYG VSSTASIPLL SASEQASTSS 480
  481 SFSVVSPSVS FVPSQSSSDV ASTSAPSVVS SSFSYTSLQA GGSSMTNPSS STIVYSSSTG 540
  541 SSEESAASTA SATLSGSSST YMAGNLQSQP PSTSSLLSES QATSTSAVLA SSSVSTTSPY 600
  601 TTAGGASTEA SSLISSTSAE TSQVSYSQST TALQTSSFAS SSTTEGSETS SQGFSTSSVL 660
  661 VQMPSSISSE FSPSQTTTQM NSASSSSQYT ISSTGILSQV SDTSVSYTTS SSSVSQVSDT 720
  721 PVSYTTSSSS VSQVSDTPVS YTTSSSSVSQ VSDTPVSYTT SSSSVSQVSD TPVSYTTSSS 780
  781 SVSQVSDTSV PSTSSRSSVS QVSDTPVPST SSRSSVSQTS SSLQPTTTSS QRFTISTHGA 840
  841 LSESSSVSQQ ASEITSSINA TASEYHSIQT TAATQSTTLS FTDANSSSAS APLEVATSTP 900
  901 TPSSKASSLL LTPSTSSLSQ VATNTNVQTS LTTESTTVLE PSTTNSSSTF SLVTSSDNNW 960
  961 WIPTELITQA PEAASTASST VGGTQTMTLP HAIAAATQVP EPEGYTLITI GFKKALNYEF1020
 1021 VVSEPKSSAQ IFGYLPEALN TPFKNVFTNI TVLQIVPLQD DSLNYLVSVA EVYFPTAEIE1080
 1081 ELSNLITNSS SAFYTDGMGT AKSMAAMVDS SIPLTGLLHD SNSNSGGSSD GSSSSNSNSG1140
 1141 SSGSGSNSNS GVSSSSGNSY QDAGTLEYSS KSNSNVSTSS KSKKKIIGLV IGVVVGGCLY1200
 1201 ILFMIFAFKY IIRRRIQSQE IIKNPEISSI SSSEFGGEKN YNNEKRMSVQ ESITQSMRIQ1260
 1261 NWMDDSYYGH GLTNNDSTPT RHNTSSSIPK ISRPIASQNS LGWNEV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MSB2 YGR149W
    View Details Qiu et al. (2008) MSB2 RHO1 SLG1 SLN1 STE3 WSC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MSB2 BNI4 2 Drees BL, et al. (2001)
    View Screen MSB2 CLA4 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] deduced N/A No confident structure predictions are available.
    2 View Details [82..326] PSI-BLAST 8.0 No description for 2h6oA was found.
    3 View Details [327..454] deduced N/A No confident structure predictions are available.
    4 View Details [455..645] MSA 1.161989 View MSA. No confident structure predictions are available.
    5 View Details [646..873] deduced N/A No confident structure predictions are available.
    6 View Details [874..1070] MSA 1.152988 View MSA. No confident structure predictions are available.
    7 View Details [1071..1223] MSA 1.118986 View MSA. No confident structure predictions are available.
    8 View Details [1224..1306] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle