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Protein Overview: SLN1

General Information:
Name(s) found: SLN1 / YIL147C [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1220 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISSLink to PubMed article]
    Biological Process: osmosensory signaling pathway via two-component system [IDALink to PubMed article]
    response to hydrogen peroxide [IMPLink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    Molecular Function: two-component sensor activity [TASLink to PubMed article]
    osmosensor activity [IDALink to PubMed article][TASLink to PubMed article]
    protein histidine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFGLPSKLE LTPPFRIGIR TQLTALVSIV ALGSLIILAV TTGVYFTSNY KNLRSDRLYI  60
   61 AAQLKSSQID QTLNYLYYQA YYLASRDALQ SSLTSYVAGN KSADNWVDSL SVIQKFLSSS 120
  121 NLFYVAKVYD SSFNAVLNAT NNGTGDLIPE DVLDSLFPLS TDTPLPSSLE TIGILTDPVL 180
  181 NSTDYLMSMS LPIFANPSII LTDSRVYGYI TIIMSAEGLK SVFNDTTALE HSTIAIISAV 240
  241 YNSQGKASGY HFVFPPYGSR SDLPQKVFSI KNDTFISSAF RNGKGGSLKQ TNILSTRNTA 300
  301 LGYSPCSFNL VNWVAIVSQP ESVFLSPATK LAKIITGTVI AIGVFVILLT LPLAHWAVQP 360
  361 IVRLQKATEL ITEGRGLRPS TPRTISRASS FKRGFSSGFA VPSSLLQFNT AEAGSTTSVS 420
  421 GHGGSGHGSG AAFSANSSMK SAINLGNEKM SPPEEENKIP NNHTDAKISM DGSLNHDLLG 480
  481 PHSLRHNDTD RSSNRSHILT TSANLTEARL PDYRRLFSDE LSDLTETFNT MTDALDQHYA 540
  541 LLEERVRART KQLEAAKIEA EAANEAKTVF IANISHELRT PLNGILGMTA ISMEETDVNK 600
  601 IRNSLKLIFR SGELLLHILT ELLTFSKNVL QRTKLEKRDF CITDVALQIK SIFGKVAKDQ 660
  661 RVRLSISLFP NLIRTMVLWG DSNRIIQIVM NLVSNALKFT PVDGTVDVRM KLLGEYDKEL 720
  721 SEKKQYKEVY IKKGTEVTEN LETTDKYDLP TLSNHRKSVD LESSATSLGS NRDTSTIQEE 780
  781 ITKRNTVANE SIYKKVNDRE KASNDDVSSI VSTTTSSYDN AIFNSQFNKA PGSDDEEGGN 840
  841 LGRPIENPKT WVISIEVEDT GPGIDPSLQE SVFHPFVQGD QTLSRQYGGT GLGLSICRQL 900
  901 ANMMHGTMKL ESKVGVGSKF TFTLPLNQTK EISFADMEFP FEDEFNPESR KNRRVKFSVA 960
  961 KSIKSRQSTS SVATPATNRS SLTNDVLPEV RSKGKHETKD VGNPNMGREE KNDNGGLEQL1020
 1021 QEKNIKPSIC LTGAEVNEQN SLSSKHRSRH EGLGSVNLDR PFLQSTGTAT SSRNIPTVKD1080
 1081 DDKNETSVKI LVVEDNHVNQ EVIKRMLNLE GIENIELACD GQEAFDKVKE LTSKGENYNM1140
 1141 IFMDVQMPKV DGLLSTKMIR RDLGYTSPIV ALTAFADDSN IKECLESGMN GFLSKPIKRP1200
 1201 KLKTILTEFC AAYQGKKNNK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARF2 COX2 MMF1 SLN1 YDR018C YDR374C
    View Details Ho Y, et al. (2002) COP1 SLN1
    View Details Qiu et al. (2008) MID2 MSB2 SHO1 SLN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] MSA 1.004953 View MSA. No confident structure predictions are available.
    2 View Details [162..264] deduced N/A No confident structure predictions are available.
    3 View Details [265..553] MSA 3.553989 View MSA. No confident structure predictions are available.
    4 View Details [554..670] ORFEUS 14.04 EnvZ histidine kinase
    5 View Details [671..785] MSA 4.272994 View MSA. Confident ab initio structure predictions are available.
    6 View Details [786..939] PSI-BLAST 81.68867 Histidine kinase domain of the osmosensor EnvZ
    7 View Details [940..1085] PSI-BLAST 13.69897 Transcriptional regulatory protein DctD, receiver domain
    8 View Details [1086..1220] PSI-BLAST 123.156545 CheY protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • two-component response regulator activity
    		•  6.41182973389827 bayes_pls_golite062009
  • molecular transducer activity
    		•  6.27803885496668 bayes_pls_golite062009
  • signal transducer activity
    		•  6.27803885496668 bayes_pls_golite062009
  • protein kinase activity
    		•  2.91563392647119 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.4588656102875 bayes_pls_golite062009
  • kinase activity
    		•  2.26401916756851 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23448171655589 bayes_pls_golite062009
  • binding
    		•  1.92400975854452 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.64567362100773 bayes_pls_golite062009
  • protein histidine kinase activity
    		•  1.60632989169905 bayes_pls_golite062009
  • two-component sensor activity
    		•  1.58303578136745 bayes_pls_golite062009
  • DNA binding
    		•  1.58172125522651 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.56306133971215 bayes_pls_golite062009
  • phosphotransferase activity, nitrogenous group as acceptor
    		•  1.45748315828993 bayes_pls_golite062009
  • receptor activity
    		•  1.17008073803454 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.10773580590429 bayes_pls_golite062009
  • transcription factor activity
    		•  0.970571914515176 bayes_pls_golite062009
  • transferase activity
    		•  0.626277634156636 bayes_pls_golite062009
    7
    Term Confidence Notes
  • two-component response regulator activity
    		•  6.41182973389827 bayes_pls_golite062009
  • molecular transducer activity
    		•  6.27803885496668 bayes_pls_golite062009
  • signal transducer activity
    		•  6.27803885496668 bayes_pls_golite062009
  • protein kinase activity
    		•  2.91563392647119 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.4588656102875 bayes_pls_golite062009
  • kinase activity
    		•  2.26401916756851 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23448171655589 bayes_pls_golite062009
  • binding
    		•  1.92400975854452 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.64567362100773 bayes_pls_golite062009
  • protein histidine kinase activity
    		•  1.60632989169905 bayes_pls_golite062009
  • two-component sensor activity
    		•  1.58303578136745 bayes_pls_golite062009
  • DNA binding
    		•  1.58172125522651 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.56306133971215 bayes_pls_golite062009
  • phosphotransferase activity, nitrogenous group as acceptor
    		•  1.45748315828993 bayes_pls_golite062009
  • receptor activity
    		•  1.17008073803454 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.10773580590429 bayes_pls_golite062009
  • transcription factor activity
    		•  0.970571914515176 bayes_pls_golite062009
  • transferase activity
    		•  0.626277634156636 bayes_pls_golite062009
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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