YRC Public Data Repository - Protein Structure Prediction

Protein:	SLN1
Organism:	Saccharomyces cerevisiae
Length:	1220 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLN1.

Description	E-value	Query Range	Subject Range
SLN1 - Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intra... SLN1_YEAST - Osmosensing histidine protein kinase SLN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...	0.0	[1..1220]	[1..1220]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[333..1208]	[272..1204]
gi\|7470855 - pir\|\|S75130 sensory transduction histidine kinase slr2098 - Synechocystis sp. (strain PCC 6803) gi\|1653075, gi\|1... - gi\|1653075\|dbj\|BAA17992.1\| hybrid sensory kinase [Synechocystis sp. PCC 6803], gi\|16330584\|ref\|NP_44...	0.0	[299..1210]	[158..1042]
gi\|13591555 - gi\|13591555\|dbj\|BAB40947.1\| histidine kinase [Magnaporthe grisea]	0.0	[328..1208]	[286..1221]
gi\|17226812 - gi\|17226812\|gb\|AAL37947.1\|AF396827_1 two-component osmosensing histidine-kinase [Botryotinia fuckeli...	0.0	[328..1208]	[287..1226]
gi\|229345095, gi... - gi\|229518380\|ref\|ZP_04407824.1\| hypothetical protein VCC_002404 [Vibrio cholerae RC9], gi\|229345095\|... gi\|229608072, gi... - gi\|229608072\|ref\|YP_002878720.1\| hypothetical protein VCD_002990 [Vibrio cholerae MJ-1236], gi\|22937... gi\|254844176, gi... - gi\|75829735\|ref\|ZP_00759029.1\| COG0642: Signal transduction histidine kinase [Vibrio cholerae MO10],... gi\|9655841, gi\|1... - gi\|9655841\|gb\|AAF94507.1\| sensory box sensor histidine kinase/response regulator [Vibrio cholerae O1... gi\|11356150 - pir\|\|H82211 sensory box sensor histidine kinase/response regulator VC1349 [imported] - Vibrio choler... gi\|126520395, gi... - gi\|229511262\|ref\|ZP_04400741.1\| hypothetical protein VCE_002669 [Vibrio cholerae B33], gi\|229351227\|...	0.0	[480..1211]	[402..1110]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFGLPSKLE LTPPFRIGIR TQLTALVSIV ALGSLIILAV TTGVYFTSNY KNLRSDRLYI  60
   61 AAQLKSSQID QTLNYLYYQA YYLASRDALQ SSLTSYVAGN KSADNWVDSL SVIQKFLSSS 120
  121 NLFYVAKVYD SSFNAVLNAT NNGTGDLIPE DVLDSLFPLS T

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [162-264]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTPLPSSLET IGILTDPVLN STDYLMSMSL PIFANPSIIL TDSRVYGYIT IIMSAEGLKS  60
   61 VFNDTTALEH STIAIISAVY NSQGKASGYH FVFPPYGSRS DLP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [265-553]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKVFSIKNDT FISSAFRNGK GGSLKQTNIL STRNTALGYS PCSFNLVNWV AIVSQPESVF  60
   61 LSPATKLAKI ITGTVIAIGV FVILLTLPLA HWAVQPIVRL QKATELITEG RGLRPSTPRT 120
  121 ISRASSFKRG FSSGFAVPSS LLQFNTAEAG STTSVSGHGG SGHGSGAAFS ANSSMKSAIN 180
  181 LGNEKMSPPE EENKIPNNHT DAKISMDGSL NHDLLGPHSL RHNDTDRSSN RSHILTTSAN 240
  241 LTEARLPDYR RLFSDELSDL TETFNTMTDA LDQHYALLEE RVRARTKQL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [554-670]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAAKIEAEAA NEAKTVFIAN ISHELRTPLN GILGMTAISM EETDVNKIRN SLKLIFRSGE  60
   61 LLLHILTELL TFSKNVLQRT KLEKRDFCIT DVALQIKSIF GKVAKDQRVR LSISLFP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.04
Match:	1joyA
Description:	EnvZ histidine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [671-785]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLIRTMVLWG DSNRIIQIVM NLVSNALKFT PVDGTVDVRM KLLGEYDKEL SEKKQYKEVY  60
   61 IKKGTEVTEN LETTDKYDLP TLSNHRKSVD LESSATSLGS NRDTSTIQEE ITKRN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.806	0.009	osmosensory signaling pathway via two-component system	c.44.2	Enzyme IIB-cellobiose

Predicted Domain #6

Region A:
Residues: [786-939]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVANESIYKK VNDREKASND DVSSIVSTTT SSYDNAIFNS QFNKAPGSDD EEGGNLGRPI  60
   61 ENPKTWVISI EVEDTGPGID PSLQESVFHP FVQGDQTLSR QYGGTGLGLS ICRQLANMMH 120
  121 GTMKLESKVG VGSKFTFTLP LNQTKEISFA DMEF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.68867
Match:	1bxdA_
Description:	Histidine kinase domain of the osmosensor EnvZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	6.41182973389827	bayes_pls_golite062009
molecular transducer activity	6.27803885496668	bayes_pls_golite062009
signal transducer activity	6.27803885496668	bayes_pls_golite062009
protein kinase activity	2.91563392647119	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.4588656102875	bayes_pls_golite062009
kinase activity	2.26401916756851	bayes_pls_golite062009
transcription regulator activity	2.23448171655589	bayes_pls_golite062009
binding	1.92400975854452	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.64567362100773	bayes_pls_golite062009
protein histidine kinase activity	1.60632989169905	bayes_pls_golite062009
two-component sensor activity	1.58303578136745	bayes_pls_golite062009
DNA binding	1.58172125522651	bayes_pls_golite062009
nucleic acid binding	1.56306133971215	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	1.45748315828993	bayes_pls_golite062009
receptor activity	1.17008073803454	bayes_pls_golite062009
transmembrane receptor activity	1.10773580590429	bayes_pls_golite062009
transcription factor activity	0.970571914515176	bayes_pls_golite062009
transferase activity	0.626277634156636	bayes_pls_golite062009

Predicted Domain #7

Region A:
Residues: [940-1085]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFEDEFNPES RKNRRVKFSV AKSIKSRQST SSVATPATNR SSLTNDVLPE VRSKGKHETK  60
   61 DVGNPNMGRE EKNDNGGLEQ LQEKNIKPSI CLTGAEVNEQ NSLSSKHRSR HEGLGSVNLD 120
  121 RPFLQSTGTA TSSRNIPTVK DDDKNE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.69897
Match:	1qkkA_
Description:	Transcriptional regulatory protein DctD, receiver domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	6.41182973389827	bayes_pls_golite062009
molecular transducer activity	6.27803885496668	bayes_pls_golite062009
signal transducer activity	6.27803885496668	bayes_pls_golite062009
protein kinase activity	2.91563392647119	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.4588656102875	bayes_pls_golite062009
kinase activity	2.26401916756851	bayes_pls_golite062009
transcription regulator activity	2.23448171655589	bayes_pls_golite062009
binding	1.92400975854452	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.64567362100773	bayes_pls_golite062009
protein histidine kinase activity	1.60632989169905	bayes_pls_golite062009
two-component sensor activity	1.58303578136745	bayes_pls_golite062009
DNA binding	1.58172125522651	bayes_pls_golite062009
nucleic acid binding	1.56306133971215	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	1.45748315828993	bayes_pls_golite062009
receptor activity	1.17008073803454	bayes_pls_golite062009
transmembrane receptor activity	1.10773580590429	bayes_pls_golite062009
transcription factor activity	0.970571914515176	bayes_pls_golite062009
transferase activity	0.626277634156636	bayes_pls_golite062009

Predicted Domain #8

Region A:
Residues: [1086-1220]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSVKILVVED NHVNQEVIKR MLNLEGIENI ELACDGQEAF DKVKELTSKG ENYNMIFMDV  60
   61 QMPKVDGLLS TKMIRRDLGY TSPIVALTAF ADDSNIKECL ESGMNGFLSK PIKRPKLKTI 120
  121 LTEFCAAYQG KKNNK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	123.156545
Match:	1udrA_
Description:	CheY protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: