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Protein Overview: MID2

General Information:
Name(s) found: MID2 / YLR332W [SGD]
Description(s) found:
Found 36 descriptions.
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  • O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article]
    Biological Process: response to acid [IMPLink to PubMed article]
    response to osmotic stress [IGILink to PubMed article]
    cellular cell wall organization [IGILink to PubMed article][IMPLink to PubMed article]
    cell morphogenesis involved in conjugation [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: transmembrane receptor activity [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSFTTKNSF RLLLLILSCI STIRAQFFVQ SSSSNSSAVS TARSSVSRVS SSSSILSSSM  60
   61 VSSSSADSSS LTSSTSSRSL VSHTSSSTSI ASISFTSFSF SSDSSTSSSS SASSDSSSSS 120
  121 SFSISSTSAT SESSTSSTQT STSSSSSLSS TPSSSSSPST ITSAPSTSST PSTTAYNQGS 180
  181 TITSIINGKT ILSNHYTTVT YTPSATADSS NKSKSSGLSK KNRNIVIGCV VGIGVPLILV 240
  241 ILALIYMFCI QSSRTDFIDS DGKVVTAYRA NKFTKWWYML LGKKVSDEYH SDSPLGGSAS 300
  301 SAGGLDLDEA DDVMEQSSLF DVRIRDSDSV LPNANTADHN NTNSGGEPIN SSVASNDIIE 360
  361 EKFYDEQGNE LSPRNY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MID2 RHO1 SLG1 SLN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #27 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps3-5 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MID2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..324] ab initio 14.79 No description for 1m2vB was found.
    2 View Details [325..376] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle