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Protein Overview: PXL1

General Information:
Name(s) found: PXL1 / YKR090W [SGD]
Description(s) found:
Found 18 descriptions.
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  • LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 706 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cellular bud tip [IDALink to PubMed articleLink to PubMed article]
    cellular bud [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mating projection tip [IDALink to PubMed article]
    Biological Process: cell division [RCA]
    maintenance of cell polarity [IMP]
    cofactor transport [RCA]
    reproduction [RCA]
    Molecular Function: protein binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNSIYGSPF PKINPKVRYK TALERAGFDT KPRNPFSSQR NASTGSLQAS VKSPPITRQR  60
   61 NVSAAPSVPV TMKSAYTASS KSAYSSVKGE SDIYPPPVLE NSERRSVTPP KNSNFTSSRP 120
  121 SDISRSISRP SERASQEDPF RFERDLDRQA EQYAASRHTC KSPANKEFQA ADNFPFNFEQ 180
  181 EDAGNTEREQ DLSPIERSFM MLTQNDTASV VNSMNQTDNR GVLDQKLGKE QQKEESSIEY 240
  241 ESEGQQEDEN DIESLNFEPD PKLQMNLENE PLQDDFPEAK QEEKNTEPKI PEINVTRESN 300
  301 TPSLTMNALD SKIYPDDNFS GLESSKEQKS PGVSSSSTKV EDLSLDGLNE KRLSITSSEN 360
  361 VETPYTATNL QVEQLIAQLD DVSLSRNAKL DMNGNCLNAV DRKASRFKKS SAYLSGYPSM 420
  421 DIPVTQQTSI VQNSNTNLSR QTILVDKGDV DEDAPSESTT NGGTPIFYKF KQSNVEYSNN 480
  481 EGMGSQETFR TKLPTIEALQ LQHKRNITDL REEIDNSKSN DSHVLPNGGT TRYSSDADYK 540
  541 ETEPIEFKYP PGEGPCRACG LEVTGKRMFS KKENELSGQW HRECFKCIEC GIKFNKHVPC 600
  601 YILGDEPYCQ KHYHEENHSI CKVCSNFIEG ECLENDKVER FHVDCLNCFL CKTAITNDYY 660
  661 IFNGEIPLCG NHDMEALLKE GIDNATSTND KNNTLSKRRT RLINFN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) BNR1 BOI2 CDC11 MYO2 PEA2 PXL1 SLA2 SPA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PXL1 Sundin BA, et al. (2004)
    View Data PXL1 Sundin BA, et al. (2004)
    View Data PXL1 Sundin BA, et al. (2004)
    View Data PXL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] ORFEUS 9.74 Sec24
    2 View Details [192..419] MSA 5.169997 View MSA. No confident structure predictions are available.
    3 View Details [420..551] ORFEUS 13.19 RBP1
    4 View Details [552..617] PSI-BLAST 23.69897 Cysteine-rich (intestinal) protein, CRP, CRIP
    5 View Details [618..706] PSI-BLAST 23.69897 Cysteine-rich (intestinal) protein, CRP, CRIP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.17633019871302 bayes_pls_golite062009
  • protein binding
    		•  1.41749048987708 bayes_pls_golite062009
  • DNA binding
    		•  0.496807292975971 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.120591949731806 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0241472448802372 bayes_pls_golite062009
    5
    Term Confidence Notes
  • binding
    		•  2.17633019871302 bayes_pls_golite062009
  • protein binding
    		•  1.41749048987708 bayes_pls_golite062009
  • DNA binding
    		•  0.496807292975971 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.120591949731806 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0241472448802372 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle