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View Structure Prediction Details

Protein: PXL1
Organism: Saccharomyces cerevisiae
Length: 706 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PXL1.

Description E-value Query
Range
Subject
Range
PXL1 - LIM domain-containing protein that localizes to sites of polarized growth, required for selection an...
0.0 [1..706] [1..706]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..706] [1..706]
gi|223460550, gi... - gi|704348|gb|AAC50104.1| paxillin, gi|4506345|ref|NP_002850.1| paxillin [Homo sapiens], gi|4099533|g...
2.0E-91 [121..690] [9..512]
gi|74211631, gi|... - gi|74211631|dbj|BAE29176.1| unnamed protein product [Mus musculus], gi|74191145|dbj|BAE39404.1| unna...
3.0E-89 [121..690] [9..512]
PAXI_CHICK - Paxillin OS=Gallus gallus GN=PXN PE=1 SV=1
9.0E-84 [121..690] [9..514]
gi|11321422 - gi|11321422|gb|AAG34161.1|AF312926_1 focal contact protein paxillin [Drosophila melanogaster]
1.0E-79 [224..690] [69..511]

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Predicted Domain #1
Region A:
Residues: [1-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNSIYGSPF PKINPKVRYK TALERAGFDT KPRNPFSSQR NASTGSLQAS VKSPPITRQR  60
   61 NVSAAPSVPV TMKSAYTASS KSAYSSVKGE SDIYPPPVLE NSERRSVTPP KNSNFTSSRP 120
  121 SDISRSISRP SERASQEDPF RFERDLDRQA EQYAASRHTC KSPANKEFQA ADNFPFNFEQ 180
  181 EDAGNTEREQ D

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.74
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [192-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSPIERSFMM LTQNDTASVV NSMNQTDNRG VLDQKLGKEQ QKEESSIEYE SEGQQEDEND  60
   61 IESLNFEPDP KLQMNLENEP LQDDFPEAKQ EEKNTEPKIP EINVTRESNT PSLTMNALDS 120
  121 KIYPDDNFSG LESSKEQKSP GVSSSSTKVE DLSLDGLNEK RLSITSSENV ETPYTATNLQ 180
  181 VEQLIAQLDD VSLSRNAKLD MNGNCLNAVD RKASRFKKSS AYLSGYPS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [420-551]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIPVTQQTS IVQNSNTNLS RQTILVDKGD VDEDAPSEST TNGGTPIFYK FKQSNVEYSN  60
   61 NEGMGSQETF RTKLPTIEAL QLQHKRNITD LREEIDNSKS NDSHVLPNGG TTRYSSDADY 120
  121 KETEPIEFKY PP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.19
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [552-617]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEGPCRACGL EVTGKRMFSK KENELSGQWH RECFKCIECG IKFNKHVPCY ILGDEPYCQK  60
   61 HYHEEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.69897
Match: 1b8tA_
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.17633019871302 bayes_pls_golite062009
protein binding 1.41749048987708 bayes_pls_golite062009
DNA binding 0.496807292975971 bayes_pls_golite062009
cytoskeletal protein binding 0.120591949731806 bayes_pls_golite062009
nucleic acid binding 0.0241472448802372 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [618-706]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSICKVCSNF IEGECLENDK VERFHVDCLN CFLCKTAITN DYYIFNGEIP LCGNHDMEAL  60
   61 LKEGIDNATS TNDKNNTLSK RRTRLINFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.69897
Match: 1b8tA_
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.17633019871302 bayes_pls_golite062009
protein binding 1.41749048987708 bayes_pls_golite062009
DNA binding 0.496807292975971 bayes_pls_golite062009
cytoskeletal protein binding 0.120591949731806 bayes_pls_golite062009
nucleic acid binding 0.0241472448802372 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle