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Protein Overview: THS1

General Information:
Name(s) found: THS1 / YIL078W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Threonyl-tRNA synthetase, essential cytoplasmic protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 734 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IMPLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: translation [IMPLink to PubMed article]
    Molecular Function: threonine-tRNA ligase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASEAGVTE QVKKLSVKDS SNDAVKPNKK ENKKSKQQSL YLDPEPTFIE ERIEMFDRLQ  60
   61 KEYNDKVASM PRVPLKIVLK DGAVKEATSW ETTPMDIAKG ISKSLADRLC ISKVNGQLWD 120
  121 LDRPFEGEAN EEIKLELLDF ESDEGKKVFW HSSAHVLGES CECHLGAHIC LGPPTDDGFF 180
  181 YEMAVRDSMK DISESPERTV SQADFPGLEG VAKNVIKQKQ KFERLVMSKE DLLKMFHYSK 240
  241 YKTYLVQTKV PDGGATTVYR CGKLIDLCVG PHIPHTGRIK AFKLLKNSSC YFLGDATNDS 300
  301 LQRVYGISFP DKKLMDAHLK FLAEASMRDH RKIGKEQELF LFNEMSPGSC FWLPHGTRIY 360
  361 NTLVDLLRTE YRKRGYEEVI TPNMYNSKLW ETSGHWANYK ENMFTFEVEK ETFGLKPMNC 420
  421 PGHCLMFKSR ERSYRELPWR VADFGVIHRN EFSGALSGLT RVRRFQQDDA HIFCTHDQIE 480
  481 SEIENIFNFL QYIYGVFGFE FKMELSTRPE KYVGKIETWD AAESKLESAL KKWGGNWEIN 540
  541 AGDGAFYGPK IDIMISDALR RWHQCATIQL DFQLPNRFEL EFKSKDQDSE SYERPVMIHR 600
  601 AILGSVERMT AILTEHFAGK WPFWLSPRQV LVVPVGVKYQ GYAEDVRNKL HDAGFYADVD 660
  661 LTGNTLQKKV RNGQMLKYNF IFIVGEQEMN EKSVNIRNRD VMEQQGKNAT VSVEEVLKQL 720
  721 RNLKDEKRGD NVLA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GYP7 THS1
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 ADE3 AFR1 AHP1 ALA1 ARC1 ARF1 ATP3 CAR2 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 EGD1 ERG13 ERG6 FPR1 FRS2 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 HOM3 LRO1 LSP1 MET6 MLP2 NTF2 OLA1 OYE2 PFK1 PFK2 PIL1 PRM2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 SSZ1 TEF4 THS1 TIF1, TIF2 TMA19 TSA2 UBA1 URA1 VMA4 VMA5 WTM1 YDR341C YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data THS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68] MSA 1.121993 View MSA. No confident structure predictions are available.
    2 View Details [69..139] PSI-BLAST 2220.0 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
    3 View Details [140..322] PSI-BLAST 2220.0 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
    4 View Details [323..620] PSI-BLAST 2220.0 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
    5 View Details [621..734] PSI-BLAST 2220.0 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  6.47381405106149 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  2.99105702052936 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • binding
    		•  1.11470390774037 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.0753492604686 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.897558352141977 bayes_pls_golite062009
  • DNA binding
    		•  0.854148126675211 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.55217603492525 bayes_pls_golite062009
  • transcription factor activity
    		•  0.283508546234551 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle