Protein Overview: UBC6

General Information:
Name(s) found:	UBC6 / YER100W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway [SGD]
Organism:	Saccharomyces cerevisiae
Length:	250 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [IDA]
Biological Process:	protein polyubiquitination [TAS] ER-associated protein catabolic process [IGI ][IMP ] protein monoubiquitination [TAS]
Molecular Function:	ubiquitin-protein ligase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATKQAHKRL TKEYKLMVEN PPPYILARPN EDNILEWHYI ITGPADTPYK GGQYHGTLTF  60
   61 PSDYPYKPPA IRMITPNGRF KPNTRLCLSM SDYHPDTWNP GWSVSTILNG LLSFMTSDEA 120
  121 TTGSITTSDH QKKTLARNSI SYNTFQNVRF KLIFPEVVQE NVETLEKRKL DEGDAANTGD 180
  181 ETEDPFTKAA KEKVISLEEI LDPEDRIRAE QALRQSENNS KKDGKEPNDS SSMVYIGIAI 240
  241 FLFLVGLFMK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ATP4 GCN1 LOS1 POL5 RVB1 SEC7 TMA19 UBA1 UBC6 UTP20 YPT1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC6	MIR1	2	Uetz P, et al. (2000)
View Screen	UBC6	ARP1	2	Unpublished Fields Lab Data
View Screen	UBC6	YPK2	2	Unpublished Fields Lab Data
View Screen	UBC6	YPL261C	2	Unpublished Fields Lab Data
View Screen	UBC6	GRH1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	UBC6	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..178]	PSI-BLAST	193.917458	Ubiquitin conjugating enzyme, UBC
2	View Details	[179..250]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
small conjugating protein ligase activity	6.4298500488854	bayes_pls_golite062009
ubiquitin-protein ligase activity	6.42696952904883	bayes_pls_golite062009
acid-amino acid ligase activity	5.49452788881858	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	3.8110076681004	bayes_pls_golite062009
ligase activity	1.88059319399119	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
protein binding	0.749259816502314	bayes_pls_golite062009
binding	0.7313332818323	bayes_pls_golite062009
NEDD8 ligase activity	0.715654744941217	bayes_pls_golite062009
SUMO ligase activity	0.452109988422698	bayes_pls_golite062009
protein serine/threonine kinase activity	0.182854082413338	bayes_pls_golite062009
protein kinase activity	0.157252474301695	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.133142640608253	bayes_pls_golite062009
kinase activity	0.0500350353657541	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2