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View Structure Prediction Details

Protein: UBC6
Organism: Saccharomyces cerevisiae
Length: 250 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBC6.

Description E-value Query
Range
Subject
Range
UBC6 - Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic...
UBC6_YEAST - Ubiquitin-conjugating enzyme E2 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBC6 P...
9.0E-69 [1..250] [1..250]
gi|14484934 - gi|14484934|gb|AAK62819.1| ubiquitin conjugating enzyme 2 [Lycopersicon esculentum]
6.0E-60 [1..249] [1..236]
gi|6649660 - gi|6649660|gb|AAF21504.1| Ubc6p homolog [Mus musculus]
1.0E-59 [2..250] [9..254]
gi|194696770, gi... - gi|99866704|gb|ABF67919.1| ubiquitin conjugating enzyme 2 [Zea mays], gi|226529280|ref|NP_001149627....
6.0E-59 [1..249] [1..236]
gi|2982311 - gi|2982311|gb|AAC32141.1| probable ubiquitin-conjugating enzyme E2 [Picea mariana]
1.0E-57 [1..249] [1..234]
UBC33_ARATH - Probable ubiquitin-conjugating enzyme E2 33 OS=Arabidopsis thaliana GN=UBC33 PE=2 SV=1
4.0E-57 [1..249] [1..240]
gi|14029267 - gi|14029267|gb|AAK52609.1|AF296658_1 ubiquitin conjugating enzyme 6 [Homo sapiens]
5.0E-57 [1..250] [1..253]

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Predicted Domain #1
Region A:
Residues: [1-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATKQAHKRL TKEYKLMVEN PPPYILARPN EDNILEWHYI ITGPADTPYK GGQYHGTLTF  60
   61 PSDYPYKPPA IRMITPNGRF KPNTRLCLSM SDYHPDTWNP GWSVSTILNG LLSFMTSDEA 120
  121 TTGSITTSDH QKKTLARNSI SYNTFQNVRF KLIFPEVVQE NVETLEKRKL DEGDAANT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 193.917458
Match: 1qcqA_
Description: Ubiquitin conjugating enzyme, UBC
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 6.4298500488854 bayes_pls_golite062009
ubiquitin-protein ligase activity 6.42696952904883 bayes_pls_golite062009
acid-amino acid ligase activity 5.49452788881858 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.8110076681004 bayes_pls_golite062009
ligase activity 1.88059319399119 bayes_pls_golite062009
catalytic activity 0.891402822028799 bayes_pls_golite062009
protein binding 0.749259816502314 bayes_pls_golite062009
binding 0.7313332818323 bayes_pls_golite062009
NEDD8 ligase activity 0.715654744941217 bayes_pls_golite062009
SUMO ligase activity 0.452109988422698 bayes_pls_golite062009
protein serine/threonine kinase activity 0.182854082413338 bayes_pls_golite062009
protein kinase activity 0.157252474301695 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.133142640608253 bayes_pls_golite062009
kinase activity 0.0500350353657541 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [179-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDETEDPFTK AAKEKVISLE EILDPEDRIR AEQALRQSEN NSKKDGKEPN DSSSMVYIGI  60
   61 AIFLFLVGLF MK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle