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View Structure Prediction Details

Protein: UBC6
Organism: Saccharomyces cerevisiae
Length: 250 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBC6.

Description E-value Query
Range
Subject
Range
UBC6 - Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic...
UBC6_YEAST - Ubiquitin-conjugating enzyme E2 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBC6 P...
9.0E-69 [1..250] [1..250]
gi|14484934 - gi|14484934|gb|AAK62819.1| ubiquitin conjugating enzyme 2 [Lycopersicon esculentum]
6.0E-60 [1..249] [1..236]
gi|6649660 - gi|6649660|gb|AAF21504.1| Ubc6p homolog [Mus musculus]
1.0E-59 [2..250] [9..254]
gi|194696770, gi... - gi|99866704|gb|ABF67919.1| ubiquitin conjugating enzyme 2 [Zea mays], gi|226529280|ref|NP_001149627....
6.0E-59 [1..249] [1..236]
gi|2982311 - gi|2982311|gb|AAC32141.1| probable ubiquitin-conjugating enzyme E2 [Picea mariana]
1.0E-57 [1..249] [1..234]
UBC33_ARATH - Probable ubiquitin-conjugating enzyme E2 33 OS=Arabidopsis thaliana GN=UBC33 PE=2 SV=1
4.0E-57 [1..249] [1..240]
gi|14029267 - gi|14029267|gb|AAK52609.1|AF296658_1 ubiquitin conjugating enzyme 6 [Homo sapiens]
5.0E-57 [1..250] [1..253]

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Predicted Domain #1
Region A:
Residues: [1-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATKQAHKRL TKEYKLMVEN PPPYILARPN EDNILEWHYI ITGPADTPYK GGQYHGTLTF  60
   61 PSDYPYKPPA IRMITPNGRF KPNTRLCLSM SDYHPDTWNP GWSVSTILNG LLSFMTSDEA 120
  121 TTGSITTSDH QKKTLARNSI SYNTFQNVRF KLIFPEVVQE NVETLEKRKL DEGDAANT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 193.917458
Match: 1qcqA_
Description: Ubiquitin conjugating enzyme, UBC
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 6.4298500488854 bayes_pls_golite062009
ubiquitin-protein ligase activity 6.42696952904883 bayes_pls_golite062009
acid-amino acid ligase activity 5.49452788881858 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.8110076681004 bayes_pls_golite062009
ligase activity 1.88059319399119 bayes_pls_golite062009
catalytic activity 0.891402822028799 bayes_pls_golite062009
protein binding 0.749259816502314 bayes_pls_golite062009
binding 0.7313332818323 bayes_pls_golite062009
NEDD8 ligase activity 0.715654744941217 bayes_pls_golite062009
SUMO ligase activity 0.452109988422698 bayes_pls_golite062009
protein serine/threonine kinase activity 0.182854082413338 bayes_pls_golite062009
protein kinase activity 0.157252474301695 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.133142640608253 bayes_pls_golite062009
kinase activity 0.0500350353657541 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [179-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDETEDPFTK AAKEKVISLE EILDPEDRIR AEQALRQSEN NSKKDGKEPN DSSSMVYIGI  60
   61 AIFLFLVGLF MK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.741 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.497 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.511 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.469 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.592 a.112.1 Description not found.
View Download 0.453 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.452 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.441 a.4.8 Ribosomal protein S18
View Download 0.417 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.415 a.30.1 ROP protein
View Download 0.404 f.13.1 Family A G protein-coupled receptor-like
View Download 0.396 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.387 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.386 a.74.1 Cyclin-like
View Download 0.386 f.17.1 F1F0 ATP synthase subunit C
View Download 0.384 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.382 a.4.5 "Winged helix" DNA-binding domain
View Download 0.364 a.64.1 Saposin
View Download 0.361 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.331 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.323 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.316 a.54.1 Domain of early E2A DNA-binding protein, ADDBP
View Download 0.300 a.144.1 PABC (PABP) domain
View Download 0.294 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.285 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.281 a.7.7 BAG domain
View Download 0.269 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.266 a.6.1 Putative DNA-binding domain
View Download 0.260 a.16.1 S15/NS1 RNA-binding domain
View Download 0.260 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.260 a.16.1 S15/NS1 RNA-binding domain
View Download 0.256 a.6.1 Putative DNA-binding domain
View Download 0.253 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.250 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.244 a.2.3 Chaperone J-domain
View Download 0.239 a.60.8 HRDC-like
View Download 0.239 a.17.1 p8-MTCP1
View Download 0.233 a.4.1 Homeodomain-like
View Download 0.233 a.7.6 Ribosomal protein S20
View Download 0.230 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.226 a.118.8 TPR-like
View Download 0.223 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.217 c.47.1 Thioredoxin-like
View Download 0.213 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.209 a.3.1 Cytochrome c
View Download 0.208 a.118.1 ARM repeat
View Download 0.207 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.207 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.206 a.4.5 "Winged helix" DNA-binding domain


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