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Protein Overview: SMC4

General Information:
Name(s) found: SMC4 / YLR086W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1418 amino acids

    Gene Ontology:
    Cellular Component: nuclear condensin complex [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: mitotic chromosome condensation [IMPLink to PubMed article][TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    Molecular Function: ATPase activity [ISSLink to PubMed article]
    chromatin binding [IDALink to PubMed article][IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSPLSKRQ KRKSAQEPEL SLDQGDAEED SQVENRVNLS ENTPEPDLPA LEASYSKSYT  60
   61 PRKLVLSSGE NRYAFSQPTN STTTSLHVPN LQPPKTSSRG RDHKSYSQSP PRSPGRSPTR 120
  121 RLELLQLSPV KNSRVELQKI YDRHQSSSKQ QSRLFINELV LENFKSYAGK QVVGPFHTSF 180
  181 SAVVGPNGSG KSNVIDSMLF VFGFRANKMR QDRLSDLIHK SEAFPSLQSC SVAVHFQYVI 240
  241 DESSGTSRID EEKPGLIITR KAFKNNSSKY YINEKESSYT EVTKLLKNEG IDLDHKRFLI 300
  301 LQGEVENIAQ MKPKAEKESD DGLLEYLEDI IGTANYKPLI EERMGQIENL NEVCLEKENR 360
  361 FEIVDREKNS LESGKETALE FLEKEKQLTL LRSKLFQFKL LQSNSKLAST LEKISSSNKD 420
  421 LEDEKMKFQE SLKKVDEIKA QRKEIKDRIS SCSSKEKTLV LERRELEGTR VSLEERTKNL 480
  481 VSKMEKAEKT LKSTKHSISE AENMLEELRG QQTEHETEIK DLTQLLEKER SILDDIKLSL 540
  541 KDKTKNISAE IIRHEKELEP WDLQLQEKES QIQLAESELS LLEETQAKLK KNVETLEEKI 600
  601 LAKKTHKQEL QDLILDLKKK LNSLKDERSQ GEKNFTSAHL KLKEMQKVLN AHRQRAMEAR 660
  661 SSLSKAQNKS KVLTALSRLQ KSGRINGFHG RLGDLGVIDD SFDVAISTAC PRLDDVVVDT 720
  721 VECAQHCIDY LRKNKLGYAR FILLDRLRQF NLQPISTPEN VPRLFDLVKP KNPKFSNAFY 780
  781 SVLRDTLVAQ NLKQANNVAY GKKRFRVVTV DGKLIDISGT MSGGGNHVAK GLMKLGTNQS 840
  841 DKVDDYTPEE VDKIERELSE RENNFRVASD TVHEMEEELK KLRDHEPDLE SQISKAEMEA 900
  901 DSLASELTLA EQQVKEAEMA YVKAVSDKAQ LNVVMKNLER LRGEYNDLQS ETKTKKEKIK 960
  961 GLQDEIMKIG GIKLQMQNSK VESVCQKLDI LVAKLKKVKS ASKKSGGDVV KFQKLLQNSE1020
 1021 RDVELSSDEL KVIEEQLKHT KLALAENDTN MNETLNLKVE LKEQSEQLKE QMEDMEESIN1080
 1081 EFKSIEIEMK NKLEKLNSLL TYIKSEITQQ EKGLNELSIR DVTHTLGMLD DNKMDSVKED1140
 1141 VKNNQELDQE YRSCETQDES EIKDAETSCD NYHPMNIDET SDEVSRGIPR LSEDELRELD1200
 1201 VELIESKINE LSYYVEETNV DIGVLEEYAR RLAEFKRRKL DLNNAVQKRD EVKEQLGILK1260
 1261 KKRFDEFMAG FNIISMTLKE MYQMITMGGN AELELVDSLD PFSEGVTFSV MPPKKSWRNI1320
 1321 TNLSGGEKTL SSLALVFALH KYKPTPLYVM DEIDAALDFR NVSIVANYIK ERTKNAQFIV1380
 1381 ISLRNNMFEL AQQLVGVYKR DNRTKSTTIK NIDILNRT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRN1 SMC2 SMC4
    View Details Krogan NJ, et al. (2006) BRN1 HIS2 SMC2 SMC4 YCG1 YCS4
    View Details Gavin AC, et al. (2002) DIS3 ISW1 MAS1 MAS2 RRP4 SMC4
    View Details Ho Y, et al. (2002) ACC1 AHA1 ARO4 BUD13 CDC60 ILS1 PML1 RPA135 RPA190 RPC40 SMC4 SRP1 TRP5 URE2 VMA4
    View Details Qiu et al. (2008) ABF1 BRN1 HSK3 SMC4 TBF1 YCG1 YCS4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run RIX7 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SMC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [136..213] PSI-BLAST 4.30103 Rad50
    3 View Details [214..511] PSI-BLAST 94.045757 Heavy meromyosin subfragment
    4 View Details [512..655] PSI-BLAST 3.0 Colicin Ia; Colicin Ia, N-terminal domain
    5 View Details [656..691]
    [714..746]    		 PSI-BLAST 9.69897 Smc hinge domain
    6 View Details [692..713]
    [747..750]
    [766..784]
    [828..854]    		 PSI-BLAST 9.69897 Smc hinge domain
    7 View Details [751..765]
    [785..827]    		 PSI-BLAST 9.69897 Smc hinge domain
    8 View Details [855..918] PSI-BLAST 10.221849 Tropomyosin
    9 View Details [919..1131] PSI-BLAST 10.221849 Tropomyosin
    10 View Details [1132..1219] PSI-BLAST 3.522879 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    11 View Details [1220..1418] PSI-BLAST 170.751666 Smc head domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.87197012801422 bayes_pls_golite062009
  • protein binding
    		•  1.11054097120015 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.87613701344509 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.655291890141256 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  0.597643104953011 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.423916142680929 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.340360347691162 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.287295057420232 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.273916899375488 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.271570433187831 bayes_pls_golite062009
  • ATPase activity
    		•  0.142237490738159 bayes_pls_golite062009
  • DNA binding
    		•  0.0749274471142563 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle