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Protein Overview: ABF1

General Information:
Name(s) found: ABF1 / YKL112W [SGD]
Description(s) found:
Found 19 descriptions.
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  • DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 731 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IMPLink to PubMed article]
    nuclear chromatin [TASLink to PubMed article]
    nucleotide-excision repair factor 4 complex [IPILink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    chromatin remodeling [IMPLink to PubMed article]
    nucleotide-excision repair, DNA damage recognition [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    DNA replication [IDALink to PubMed article][TASLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article][TASLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article][TASLink to PubMed article]
    transcription factor activity [TASLink to PubMed article]
    DNA bending activity [IDALink to PubMed article]
    chromatin binding [IDALink to PubMed article][IMPLink to PubMed article][TASLink to PubMed article]
    transcription activator activity [IDALink to PubMed article][IMPLink to PubMed article]
    transcription repressor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLVVNYYE YKHPIINKDL AIGAHGGKKF PTLGAWYDVI NEYEFQTRCP IILKNSHRNK  60
   61 HFTFACHLKN CPFKVLLSYA GNAASSETSS PSANNNTNPP GTPDHIHHHS NNMNNEDNDN 120
  121 NNGSNNKVSN DSKLDFVTDD LEYHLANTHP DDTNDKVESR SNEVNGNNDD DADANNIFKQ 180
  181 QGVTIKNDTE DDSINKASID RGLDDESGPT HGNDSGNHRH NEEDDVHTQM TKNYSDVVND 240
  241 EDINVAIANA VANVDSQSNN KHDGKDDDAT NNNDGQDNNT NNDHNNNSNI NNNNVGSHGI 300
  301 SSHSPSSIRD TSMNLDVFNS ATDDIPGPFV VTKIEPYHSH PLEDNLSLGK FILTKIPKIL 360
  361 QNDLKFDQIL ESSYNNSNHT VSKFKVSHYV EESGLLDILM QRYGLTAEDF EKRLLSQIAR 420
  421 RITTYKARFV LKKKKMGEYN DLQPSSSSNN NNNNDGELSG TNLRSNSIDY AKHQEISSAG 480
  481 TSSNTTKNVN NNKNDSNDDN NGNNNNDASN LMESVLDKTS SHRYQPKKMP SVNKWSKPDQ 540
  541 ITHSDVSMVG LDESNDGGNE NVHPTLAEVD AQEARETAQL AIDKINSYKR SIDDKNGDGH 600
  601 NNSSRNVVDE NLINDMDSED AHKSKRQHLS DITLEERNED DKLPHEVAEQ LRLLSSHLKE 660
  661 VENLHQNNDD DVDDVMVDVD VESQYNKNTT HHNNHHSQPH HDEEDVAGLI GKADDEEDLS 720
  721 DENIQPELRG Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ABF1 SRL2 YHL009W-B
    View Details Qiu et al. (2008) ABF1 ARP4 ELC1 HTZ1 KAE1 MCM1 MCM4 MCM6 NHP6A PCC1 POB3 RAD1 RAD10 RAD14 RAD16 RAD23 RAD4 RAD7 RAP1 SAS3 SLD3 SMC4 SSL1 SSL2 TBF1 TFB2 TFB3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ABF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A No confident structure predictions are available.
    2 View Details [79..176] ORFEUS 7.56 No description for 1l8mA was found.
    3 View Details [177..245] ORFEUS 7.56 No description for 1l8mA was found.
    4 View Details [246..320] ORFEUS 7.56 No description for 1l8mA was found.
    5 View Details [321..481]
    [518..560]    		 ORFEUS 7.09 Monomeric isocitrate dehydrogenase
    6 View Details [482..517]
    [561..731]    		 ORFEUS 7.09 Monomeric isocitrate dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle