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Protein Overview: NHP6A

General Information:
Name(s) found: NHP6A / YPR052C [SGD]
Description(s) found:
Found 35 descriptions.
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  • High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 93 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [IPILink to PubMed article]
    Biological Process: chromatin remodeling [IMPLink to PubMed article]
    chromatin organization [IPILink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][IPILink to PubMed article]
    regulation of transcription from RNA polymerase III promoter [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: chromatin binding [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTPREPKKR TTRKKKDPNA PKRALSAYMF FANENRDIVR SENPDITFGQ VGKKLGEKWK  60
   61 ALTPEEKQPY EAKAQADKKR YESEKELYNA TLA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABF2 BFR1 HHO1 NHP6A PBP4 PUF4 RPL11B RPL17A RPL17B RPL20A RPL21A RPL29 RPL2A, RPL2B RPL3 RPL30 RPL32 RPL36A RPL42B, RPL42A RPL4A RPL6A RPL8B RPS14A RPS16B, RPS16A RPS17B RPS22A RPS23B, RPS23A RPS30B, RPS30A RPS5 RPS8B, RPS8A YHI9
    View Details Krogan NJ, et al. (2006) APN2 BFR1 BRX1 BUR2 LOC1 NHP6A PRK1 RIM1 SGV1 SPB1 TMA64 TSR1
    View Details Qiu et al. (2008) ABF1 KAE1 NHP6A PCC1 TBF1 YBR090C-A, NHP6B

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NHP6A Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 337.751666 NHP6a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.927928103499335 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.38664561645052 bayes_pls_golite062009
  • DNA binding
    		•  0.37554038880732 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle