Protein Overview: APN2

General Information:
Name(s) found:	APN2 / YBL019W [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII [SGD]
Organism:	Saccharomyces cerevisiae
Length:	520 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC]
Biological Process:	base-excision repair [IGI]
Molecular Function:	DNA-(apurinic or apyrimidinic site) lyase activity [IDA] double-stranded DNA specific 3'-5' exodeoxyribonuclease activity [IDA] phosphoric diester hydrolase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSENTLLD GKSENTIRFL TFNVNGIRTF FHYQPFSQMN QSLRSVFDFF RADIITFQEL  60
   61 KTEKLSISKW GRVDGFYSFI SIPQTRKGYS GVGCWIRIPE KNHPLYHALQ VVKAEEGITG 120
  121 YLTIKNGKHS AISYRNDVNQ GIGGYDSLDP DLDEKSALEL DSEGRCVMVE LACGIVIISV 180
  181 YCPANSNSSE EGEMFRLRFL KVLLRRVRNL DKIGKKIVLM GDVNVCRDLI DSADTLEQFS 240
  241 IPITDPMGGT KLEAQYRDKA IQFIINPDTP HRRIFNQILA DSLLPDASKR GILIDTTRLI 300
  301 QTRNRLKMYT VWNMLKNLRP SNYGSRIDFI LVSLKLERCI KAADILPDIL GSDHCPVYSD 360
  361 LDILDDRIEP GTTQVPIPKF EARYKYNLRN HNVLEMFAKK DTNKESNKQK YCVSKVMNTK 420
  421 KNSNIKNKSL DSFFQKVNGE KDDRIKESSE IPQQAKKRIS TPKLNFKDVF GKPPLCRHGE 480
  481 ESMLKTSKTS ANPGRKFWIC KRSRGDSNNT ESSCGFFQWV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		APN2 BFR1 BRX1 BUR2 LOC1 NHP6A PRK1 RIM1 SGV1 SPB1 TMA64 TSR1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NSE5	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	APN2	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
binding	1.43395324624057	bayes_pls_golite062009
nucleic acid binding	0.848172443927544	bayes_pls_golite062009
DNA binding	0.675136468766578	bayes_pls_golite062009
transcription regulator activity	0.649299186442773	bayes_pls_golite062009
protein binding	0.229377151617187	bayes_pls_golite062009
hydrolase activity	0.178972542898413	bayes_pls_golite062009
catalytic activity	0.0166038714828167	bayes_pls_golite062009

Term	Confidence	Notes
binding	1.43395324624057	bayes_pls_golite062009
nucleic acid binding	0.848172443927544	bayes_pls_golite062009
DNA binding	0.675136468766578	bayes_pls_golite062009
transcription regulator activity	0.649299186442773	bayes_pls_golite062009
protein binding	0.229377151617187	bayes_pls_golite062009
hydrolase activity	0.178972542898413	bayes_pls_golite062009
catalytic activity	0.0166038714828167	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..376]	PSI-BLAST	154.0103	DNA repair endonuclease Hap1
2	View Details	[377..520]	MSA	9.041989	View MSA. No confident structure predictions are available.

Protein Overview: APN2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: