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View Structure Prediction Details

Protein: APN2
Organism: Saccharomyces cerevisiae
Length: 520 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APN2.

Description E-value Query
Range
Subject
Range
APN2_YEAST - DNA-(apurinic or apyrimidinic site) lyase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
APN2 - Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. col...
0.0 [1..520] [1..520]
gi|5410346 - gi|5410346|gb|AAD43041.1|AF119046_1 APE2 protein [Homo sapiens]
0.0 [16..519] [1..514]
APN2_SCHPO - DNA-(apurinic or apyrimidinic site) lyase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...
apn2 - AP-endonuclease Apn2
3.0E-90 [17..519] [1..513]
gi|16904254 - gi|16904254|gb|AAL30835.1|AF440398_3 DNA lyase-like protein [Mycosphaerella graminicola]
1.0E-87 [17..496] [1..458]
gi|12862077 - gi|12862077|dbj|BAB32346.1| unnamed protein product [Mus musculus]
1.0E-80 [16..428] [1..385]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
8.0E-77 [19..480] [15..366]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
2.0E-75 [19..480] [9..360]

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Predicted Domain #1
Region A:
Residues: [1-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSENTLLD GKSENTIRFL TFNVNGIRTF FHYQPFSQMN QSLRSVFDFF RADIITFQEL  60
   61 KTEKLSISKW GRVDGFYSFI SIPQTRKGYS GVGCWIRIPE KNHPLYHALQ VVKAEEGITG 120
  121 YLTIKNGKHS AISYRNDVNQ GIGGYDSLDP DLDEKSALEL DSEGRCVMVE LACGIVIISV 180
  181 YCPANSNSSE EGEMFRLRFL KVLLRRVRNL DKIGKKIVLM GDVNVCRDLI DSADTLEQFS 240
  241 IPITDPMGGT KLEAQYRDKA IQFIINPDTP HRRIFNQILA DSLLPDASKR GILIDTTRLI 300
  301 QTRNRLKMYT VWNMLKNLRP SNYGSRIDFI LVSLKLERCI KAADILPDIL GSDHCPVYSD 360
  361 LDILDDRIEP GTTQVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 154.0103
Match: 1hd7A_
Description: DNA repair endonuclease Hap1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.43395324624057 bayes_pls_golite062009
nucleic acid binding 0.848172443927544 bayes_pls_golite062009
DNA binding 0.675136468766578 bayes_pls_golite062009
transcription regulator activity 0.649299186442773 bayes_pls_golite062009
protein binding 0.229377151617187 bayes_pls_golite062009
hydrolase activity 0.178972542898413 bayes_pls_golite062009
catalytic activity 0.0166038714828167 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [377-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPKFEARYKY NLRNHNVLEM FAKKDTNKES NKQKYCVSKV MNTKKNSNIK NKSLDSFFQK  60
   61 VNGEKDDRIK ESSEIPQQAK KRISTPKLNF KDVFGKPPLC RHGEESMLKT SKTSANPGRK 120
  121 FWICKRSRGD SNNTESSCGF FQWV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.43395324624057 bayes_pls_golite062009
nucleic acid binding 0.848172443927544 bayes_pls_golite062009
DNA binding 0.675136468766578 bayes_pls_golite062009
transcription regulator activity 0.649299186442773 bayes_pls_golite062009
protein binding 0.229377151617187 bayes_pls_golite062009
hydrolase activity 0.178972542898413 bayes_pls_golite062009
catalytic activity 0.0166038714828167 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle