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Protein Overview: KAE1

General Information:
Name(s) found: KAE1 / YKR038C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Highly conserved putative glycoprotease proposed to be involved in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 386 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear chromatin [IDALink to PubMed article]
    EKC/KEOPS protein complex [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: telomere maintenance [IPILink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: chromatin DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNLNTIPPK NGRDYYIALG LEGSANKLGV GIVKHPLLPK HANSDLSYDC EAEMLSNIRD  60
   61 TYVTPPGEGF LPRDTARHHR NWCIRLIKQA LAEADIKSPT LDIDVICFTK GPGMGAPLHS 120
  121 VVIAARTCSL LWDVPLVGVN HCIGHIEMGR EITKAQNPVV LYVSGGNTQV IAYSEKRYRI 180
  181 FGETLDIAIG NCLDRFARTL KIPNEPSPGY NIEQLAKKAP HKENLVELPY TVKGMDLSMS 240
  241 GILASIDLLA KDLFKGNKKN KILFDKTTGE QKVTVEDLCY SLQENLFAML VEITERAMAH 300
  301 VNSNQVLIVG GVGCNVRLQE MMAQMCKDRA NGQVHATDNR FCIDNGVMIA QAGLLEYRMG 360
  361 GIVKDFSETV VTQKFRTDEV YAAWRD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CGI121 GON7 GRX4 KAE1
    View Details Hazbun TR, et al. (2003) GON7 KAE1
    View Details Krogan NJ, et al. (2006) CGI121 GON7 KAE1
    View Details Gavin AC, et al. (2006) CGI121 GON7 KAE1
    View Details Ho Y, et al. (2002) AAC3 BUD32 CAR2 CGI121 CPR6 CRM1 DIA4 GRX3 GRX4 HEF3 IDP2 IMD2 IMD4 KAE1 NPA3 PHO81 POR1 RNH202 RPN1 RPN5 RPN6 RPT1 RPT3 SEC18 SEC23 SGO1 TMA29 URA7 YHR033W
    View Details Qiu et al. (2008) ABF1 ARP4 CGI121 FPR4 GON7 KAE1 NHP6A PCC1 RED1 TBF1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KAE1 and SPC42 Hazbun TR, et al. (2003)
    View Data KAE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..386] PSI-BLAST 79.30103 No description for 2ivnA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle