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Protein Overview: IDP2

General Information:
Name(s) found: IDP2 / YLR174W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 412 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: glutamate biosynthetic process [TASLink to PubMed article]
    isocitrate metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: isocitrate dehydrogenase (NADP+) activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKIKVANPI VEMDGDEQTR IIWHLIRDKL VLPYLDVDLK YYDLSVEYRD QTNDQVTVDS  60
   61 ATATLKYGVA VKCATITPDE ARVEEFHLKK MWKSPNGTIR NILGGTVFRE PIIIPRIPRL 120
  121 VPQWEKPIII GRHAFGDQYK ATDVIVPEEG ELRLVYKSKS GTHDVDLKVF DYPEHGGVAM 180
  181 MMYNTTDSIE GFAKASFELA IERKLPLYST TKNTILKKYD GKFKDVFEAM YARSYKEKFE 240
  241 SLGIWYEHRL IDDMVAQMLK SKGGYIIAMK NYDGDVESDI VAQGFGSLGL MTSVLITPDG 300
  301 KTFESEAAHG TVTRHFRQHQ QGKETSTNSI ASIFAWTRGI IQRGKLDNTP DVVKFGQILE 360
  361 SATVNTVQED GIMTKDLALI LGKSERSAYV TTEEFIDAVE SRLKKEFEAA AL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAC3 BUD32 CAR2 CPR6 CRM1 DIA4 GRX3 GRX4 HEF3 IDP2 IMD2 IMD4 KAE1 NPA3 PHO81 RNH202 RPN1 RPN5 RPN6 RPT1 SEC18 SEC23 SGO1 TMA29 URA7 YHR033W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..412] PSI-BLAST 138.9897 3-isopropylmalate dehydrogenase, IPMDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • isocitrate dehydrogenase (NAD+) activity
    		•  5.9567768649084 bayes_pls_golite062009
  • isocitrate dehydrogenase activity
    		•  5.76817846591752 bayes_pls_golite062009
  • isocitrate dehydrogenase (NADP+) activity
    		•  3.47645456015586 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.74237430402883 bayes_pls_golite062009
  • catalytic activity
    		•  2.71251959637136 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.46799258909805 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  2.38235863668553 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15484868227001 bayes_pls_golite062009
  • 3-isopropylmalate dehydrogenase activity
    		•  0.848289435089509 bayes_pls_golite062009
  • binding
    		•  0.530580225668688 bayes_pls_golite062009
  • protein binding
    		•  0.074256700284446 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle