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View Structure Prediction Details

Protein: IDP2
Organism: Saccharomyces cerevisiae
Length: 412 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IDP2.

Description E-value Query
Range		 Subject
Range
IDHP_BOVIN - (Q04467) Isocitrate dehydrogenase [NADP], mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate deca...
 0.0 [2..410] [42..452]
gi|27370516, gi|... - gi|27370516|ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus], gi|12...
 0.0 [2..410] [42..452]
gi|1750380 - gi|1750380|gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus globulus]
 0.0 [3..412] [5..415]
IDHP_PIG - Isocitrate dehydrogenase [NADP], mitochondrial (Fragment) OS=Sus scrofa GN=IDH2 PE=1 SV=1
gi|284570 - pir||A43294 isocitrate dehydrogenase (NADP) (EC 1.1.1.42), mitochondrial - pig
 0.0 [2..410] [11..421]
gi|123998944, gi... - gi|123998944|gb|ABM87062.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic construct],...
IDH2 - isocitrate dehydrogenase 2 (NADP+), mitochondrial
 0.0 [2..410] [42..452]
IDHC_TOBAC - Isocitrate dehydrogenase [NADP] OS=Nicotiana tabacum PE=2 SV=1
 0.0 [3..411] [5..414]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..411] [5..414]
gi|169989 - gi|169989|gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase
 0.0 [2..409] [33..441]

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Predicted Domain #1
Region A:
Residues: [1-412] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKIKVANPI VEMDGDEQTR IIWHLIRDKL VLPYLDVDLK YYDLSVEYRD QTNDQVTVDS  60
   61 ATATLKYGVA VKCATITPDE ARVEEFHLKK MWKSPNGTIR NILGGTVFRE PIIIPRIPRL 120
  121 VPQWEKPIII GRHAFGDQYK ATDVIVPEEG ELRLVYKSKS GTHDVDLKVF DYPEHGGVAM 180
  181 MMYNTTDSIE GFAKASFELA IERKLPLYST TKNTILKKYD GKFKDVFEAM YARSYKEKFE 240
  241 SLGIWYEHRL IDDMVAQMLK SKGGYIIAMK NYDGDVESDI VAQGFGSLGL MTSVLITPDG 300
  301 KTFESEAAHG TVTRHFRQHQ QGKETSTNSI ASIFAWTRGI IQRGKLDNTP DVVKFGQILE 360
  361 SATVNTVQED GIMTKDLALI LGKSERSAYV TTEEFIDAVE SRLKKEFEAA AL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 138.9897
Match: 1cnzA_
Description: 3-isopropylmalate dehydrogenase, IPMDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
isocitrate dehydrogenase (NAD+) activity 5.9567768649084 bayes_pls_golite062009
isocitrate dehydrogenase activity 5.76817846591752 bayes_pls_golite062009
isocitrate dehydrogenase (NADP+) activity 3.47645456015586 bayes_pls_golite062009
oxidoreductase activity 2.74237430402883 bayes_pls_golite062009
catalytic activity 2.71251959637136 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 2.46799258909805 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2.38235863668553 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.15484868227001 bayes_pls_golite062009
3-isopropylmalate dehydrogenase activity 0.848289435089509 bayes_pls_golite062009
binding 0.530580225668688 bayes_pls_golite062009
protein binding 0.074256700284446 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle