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Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: isocitrate dehydrogenase activity
Acc: GO:0004448
Aspect: Molecular Function
Desc: Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
Synonyms:
  • oxalosuccinate carboxylase activity
  • isocitric dehydrogenase activity
  • beta-ketoglutaric-isocitric carboxylase activity
  • oxalsuccinic decarboxylase activity
  • oxalosuccinate decarboxylase activity
  • IDH activity
  • IDP3
  • IDP activity
  • IDP1
  • isocitric acid dehydrogenase activity
  • IDP2
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 70 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004448 - isocitrate dehydrogenase activity (interactive image map)
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Created and Maintained by: Michael Riffle