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Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 3-isopropylmalate dehydrogenase activity
Acc: GO:0003862
Aspect: Molecular Function
Desc: Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
Synonyms:
  • IPMDH
  • threo-Ds-3-isopropylmalate dehydrogenase activity
  • beta-IPM dehydrogenase activity
  • beta-isopropylmalic enzyme
  • IMDH activity
  • beta-isopropylmalate dehydrogenase activity
  • 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity
  • (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity
Proteins in PDR annotated with:
   This term: 21 [Search]
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003862 - 3-isopropylmalate dehydrogenase activity (interactive image map)
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