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Protein Overview: CGI121

General Information:
Name(s) found: CGI121 / YML036W [SGD]
Description(s) found:
Found 17 descriptions.
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  • Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 189 amino acids

    Gene Ontology:
    Cellular Component: EKC/KEOPS protein complex [IDALink to PubMed articleLink to PubMed article]
    Biological Process: telomere maintenance [IGILink to PubMed article][IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVSIIPQFP DIKVSLALFE QVKNAKEIRS KMSELSTSFA FIDPRLVCSG EQMYSAIYKT  60
   61 LIEVKYNKMR TRNLNSECVL CLSPTSNISD AFLKFGIKDD SSQLICLKFH TNTDDVDKEQ 120
  121 LRTIMTSIVK GQEIEFNDDN LSRFYDEALI RKVCFNNKFE VKTSTASPET HCTNFTFVFL 180
  181 LFCFYLLDL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BUD32 CGI121 GON7 GRX4 KAE1
    View Details Krogan NJ, et al. (2006) CGI121 GON7 KAE1
    View Details Gavin AC, et al. (2006) CGI121 GON7 KAE1
    View Details Ho Y, et al. (2002) BUD32 CGI121 GRX4 KAE1 POR1 RPT3
    View Details Qiu et al. (2008) BUD32 CGI121 GON7 KAE1 PCC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle