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Protein Overview: CAB4

General Information:
Name(s) found: CAB4 / YGR277C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 305 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: coenzyme A biosynthetic process [ISSLink to PubMed article]
    Molecular Function: pantetheine-phosphate adenylyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEENSRVLI VLPYTPPSAT LQRIIGQTIP FLRECQSQLD IVIVPEFKTS FQLDSALGKM  60
   61 YSITRDVLLG YGMINSGINI IFNNIHFVES NLQWKVVLLP QESTFETWKL ELGQGQYHSI 120
  121 EHYALHDNIM EEIEGPKDAN KFHVTALGGT FDHIHDGHKI LLSVSTFITS QRLICGITCD 180
  181 ELLQNKKYKE LIEPYDTRCR HVHQFIKLLK PDLSVELVPL RDVCGPTGKV PEIECLVVSR 240
  241 ETVSGAETVN KTRIEKGMSP LAVHVVNVLG GREEDGWSEK LSSTEIRRLL KSSASPTCTP 300
  301 QNPCV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAB4 YLH47

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CAB4 BUD9 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CAB4 and SPC42 Hazbun TR, et al. (2003)
    View Data CAB4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] MSA 7.047988 View MSA. Confident ab initio structure predictions are available.
    2 View Details [119..305] PSI-BLAST 23.045757 CTP:glycerol-3-phosphate cytidylyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • pantetheine-phosphate adenylyltransferase activity
    		•  2.8881527826831 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  2.80953822781392 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  2.80953822781392 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  2.79852902055493 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • ligase activity
    		•  2.038397138176 bayes_pls_golite062009
  • adenylyltransferase activity
    		•  1.08055019963499 bayes_pls_golite062009
  • pantoate-beta-alanine ligase activity
    		•  1.07698847477799 bayes_pls_golite062009
  • binding
    		•  0.965037527908742 bayes_pls_golite062009
  • nicotinate-nucleotide adenylyltransferase activity
    		•  0.692499879958128 bayes_pls_golite062009
  • nicotinamide-nucleotide adenylyltransferase activity
    		•  0.567882194154248 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.427749234863188 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.311743335409574 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  0.142322351925094 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.097721445469396 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle