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Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: L-malate dehydrogenase activity
Acc: GO:0030060
Aspect: Molecular Function
Desc: Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
Synonyms:
  • L-malate-NAD+ oxidoreductase activity
  • NAD-dependent malate dehydrogenase activity
  • NAD-L-malate dehydrogenase activity
  • NAD-specific malate dehydrogenase activity
  • NAD-malic dehydrogenase activity
  • MDH
  • malic acid dehydrogenase activity
  • NAD-linked malate dehydrogenase activity
  • (S)-malate:NAD+ oxidoreductase activity
  • NAD-malate dehydrogenase activity
  • malate (NAD) dehydrogenase activity
  • NAD-dependent malic dehydrogenase activity
  • malic dehydrogenase activity
Proteins in PDR annotated with:
   This term: 39 [Search]
   Term or descendants: 39 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030060 - L-malate dehydrogenase activity (interactive image map)
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