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Protein Overview: VHS1

General Information:
Name(s) found: VHS1 / YDR247W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 461 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]
    protein serine/threonine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMFHNCRIN NYLITSQIGE GAYGLVYRAL DIRTDRQYAI KAVVQSYGVS KEADMGNDKI  60
   61 HKNSVKLQKK LAKLFKESKN VVRVPSIDLE SIENMSEEDF KKLPHYKEIS LHLRVHHHKN 120
  121 IVTIHEVLQS AVCTFIVMDY YPTDLFTSIV DNRHFVTNGL LVKKVFLQIC SALNYCHEHG 180
  181 IYHCDIKPEN LLLDTEDNVF LCDFGLSTTS TYIKPNVCIG SSYYMPPERI SFDGRVSSSK 240
  241 SGGHKLGKVC PSCNGDLWSL GIILINLTCI RNPWLKADKT EDNTYYYFTK DPNILKQILP 300
  301 LSDDFYSLLS KILQVNPKNR MSLQELMKEV SSITSFTNEG PLSKVPPLSK SVYEKFVSPV 360
  361 DNTNENLSPK SYVYMHDSKA AKNLSYTSSS EEEDGIKEGI DDDNGSRSGS FGTLDTDTGL 420
  421 HSSFTSTSCE SDNECSKISN KFSLFEKKFN ELRMSSSSLT N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) GIN4 MER1 NUM1 PAA1 PTC4 SEF1 SKT5 SPT16 SYF1 TPS1 VHS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VHS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110]
    [124..140]    		 PSI-BLAST 195.512579 Cyclin-dependent PK, CDK2
    2 View Details [111..123]
    [141..208]    		 PSI-BLAST 195.512579 Cyclin-dependent PK, CDK2
    3 View Details [209..336] PSI-BLAST 195.512579 Cyclin-dependent PK, CDK2
    4 View Details [337..461] PSI-BLAST 4.09691 Troponin C


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle